The aim of the research was to evaluate and test the influence of organic coordination compounds containing rare microelements, on the vital functions and on the development of the morpho-character of Apis mellifera bee colonies. Several experiments where conducted and was tested in feeding bees in spring (April 1 to 21) a period with poor harvest in nature, a nutritious blend of 50% sugar syrup supplement enriched with bioactive organic compound heteronuclear coordinative sulfate [tris-thiosemicarbazide cobalt (III)] [1, 2-diaminociclohexantetraacetat bismuth (III)] hexahydrate - [Co (tios) 3], [Bi (CDTA)] SO4 · 6H2O in aqueous solution with concentration of 1 mg% (hereinafter referred to as "compound + Co + Bi), which was mixed with sugar syrup in a ratio of 2: 100, and was administered directly into the food of bees and bee families where feed with the nutrient in amount of 100 ... 130 ml for every frame with bees, every 2 days for a period of three weeks. Bee colonies were formed into three lots, each lot formed from 16 families, of which: group I - control, which were fed only with sugar syrup 50%, group II - prototype, which where feed with sugar syrup by adding nutritional supplement enriched with patented "Apispir + Fe + It" (MD 477 Z 2012.09.30) and group III - experimental, which received sugar syrup enriched with supplement "compound + Co + Bi". The research results have shown that using energizing nutritional supplements enriched with biologically active substances of organic compounds coordination in bee feeding in times when there is a poor harvest in nature, helps stimulate vital functions of bee families and increase their productivity: the prolificity of queen - with 5.2 to 9.7% (P <0.001); the amount of capped brood - with 5.2 to 9.7% (P <0.001); family strenght- by 2.5 to 9.7% (P <0.1s P <0.001); disease resistance - by 2.4 to 5.0% (P <0.001); brood viability - with 1.2 to 2.2% (P <0,01s (P <0.001); the amount of accumulated bee bread in brood chamber- by 15.0 to 23.3% (P <0.001), an increased amount of wax combs - by 21.4 to 39.3% (P <0.001) and the amount of honey accumulated in the colony - with 13.9 to 25.4% (P <0.01 and P <0.001). The beneficial effect of feeding bees with biologically active nutritional supplements Apispir + Fe + + Co + Se and Bi compound denotes the fact that in the spring (March-April), a period poor in harvesting, in the area studied, in nature there is a shortage of biologically active substances, including rare microelements.