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SM ISO690:2012 LUNGU, Lidia, CIOCARLAN, Alexandru, VICOL, Crina, ILKER, Ozer, SHOVA, Sergiu, GUŢU, Iacob, VORNICU, Nicoleta, MANGALAGIU, Ionel I., AMBROSIO, Michele, ARICU, Aculina. Synthesis and Evaluation of Biological Activity of Homodrimane Sesquiterpenoids Bearing 1,3,4-Oxadiazole or 1,3,4-Thiadiazole Units. In: Chemistry of Heterocyclic Compounds, 2020, vol. 56, pp. 578-585. ISSN 0009-3122. DOI: https://doi.org/10.1007/s10593-020-02703-7 |
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Chemistry of Heterocyclic Compounds | |
Volumul 56 / 2020 / ISSN 0009-3122 /ISSNe 1573-8353 | |
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DOI:https://doi.org/10.1007/s10593-020-02703-7 | |
Pag. 578-585 | |
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Rezumat | |
Synthesis of novel (+)-sclareolide-based homodrimane sesquiterpenoids bearing 1,3,4-oxadiazole or 1,3,4-thiadiazole units has been reported. These terpeno-heterocyclic compounds demonstrate promising antifungal and antibacterial activities toward fungal species Aspergillus niger, Fusarium solani, Penicillium chrysogenum, Penicillium frequentans, and Alternaria alternata and bacteria strains Pseudomonas aeruginosa and Bacillus sp. with minimum inhibitory concentration at μg/ml level. |
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Cuvinte-cheie antibacterial activity, Antifungal activity, homodrimane sesquiterpenoid, oxadiazole, Thiadiazole |
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