Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
957 40 |
Ultima descărcare din IBN: 2024-04-21 22:59 |
Căutarea după subiecte similare conform CZU |
547.583.5:615.281 (1) |
Chimie organică (484) |
Medicamentele potrivit acţiunii lor principale (395) |
SM ISO690:2012 HRICHI, Hajer, AHMED ELKANZI, Nadia Ali, BADAWY BAKR, Rania. Novel β-lactams and thiazolidinone derivatives from 1,4-dihydroquinoxaline schiff’s base: synthesis, antimicrobial activity and molecular docking studies. In: Chemistry Journal of Moldova, 2020, nr. 1(15), pp. 86-94. ISSN 1857-1727. DOI: https://doi.org/10.19261/cjm.2019.647 |
EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
Chemistry Journal of Moldova | ||||||
Numărul 1(15) / 2020 / ISSN 1857-1727 /ISSNe 2345-1688 | ||||||
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DOI:https://doi.org/10.19261/cjm.2019.647 | ||||||
CZU: 547.583.5:615.281 | ||||||
Pag. 86-94 | ||||||
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Rezumat | ||||||
A series of novel isolated β-lactams 3a-c and thiazolidinone derivatives 4a-c were successfully synthesized from reactions of new Schiff's bases 2a-c with chloroacetyl chloride and thioglycolic acid. The chemical structures of the new compounds were confirmed through different spectroscopic techniques including IR, 1H and 13C NMR, mass spectrometry and elemental analysis. The antimicrobial activity of the obtained compounds was assessed in vitro against gram-positive Staphylococcus aureus and gram-negative Escherichia coli bacteria and Aspergillus flavus and Candida albicans fungi. All compounds exhibited good to excellent antimicrobial activity against the tested strains. Furthermore, a molecular docking study was carried out for the synthesized compounds and the results indicated that compounds 3b and 4b display comparable binding affinity scores as that of glutamate. These two compounds are promising candidates as antibacterial and antifungal agents that would deserve further investigations. |
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Cuvinte-cheie Heterocycle, β-lactam, quinoxaline, Antimicrobial activity, Molecular docking |
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