In the specialty literature, more attention is paid to the antibacterial preparations and
antifungal polymeric preparations with prolonged properties and other features that are
successfully used in pharmaceutical practice [1-2].
In our work we have synthesized many copolymers with medicinal properties of the N-vinyl
pyrrolidone, methacrylic acid (1:1), or starch and dextran engrafted with furacilin (I) and butyl
ester of the 5-nytro-2-furfulidencarbazil acid (NACS) and other nitrofuran derivatives according to the following scheme:

The structure of biologically active copolymers was confirmed by IR spectroscopy and by
elemental analysis. From IR spectrum it was evident the appearance of NO2 group (=820 cm-1
si 1510 cm-1) as well as the increase of the intensity of the band peak with =1720 cm-1
characteristic of the carbonyl group for N-VP: ACM engrafted with 5-nitro 2-furfurjlidenecarbazilic
ester as well as the emergence of other new features of the biologically active
copolymer.
The medical test of copolymer with furacilin (I) and with 5-nitro-2- furfurjlidene-carbazilic
ester proved antimicrobial and antimycotic essential action against the Gram-negative and Grampositive
cultures. These properties allow the use of biologically active copolymers in
pharmaceutical practice.
References:
1. Платэ Н. Васильев А., Физиологически активные полимеры, Моссква, ”Наука”, 1987.
2. S. Robu1, V. Filip1, V. Prisacari2, A. Dizdari2, P. Gheoaca3, B. Spurcaci3, I. Culeac4, ”Synthesis
and Characterization of Copolymers Based on Styrene-Butadiene Grafted with Antimicrobial
Agents”, 2nd International Conference on Nanotechnologies and Biomedical Engineering,
Chişinău, Republic of Moldova, April 18-20, 2013.