The paper presents the synthesis of complex combinations of Cu(II) with Schiff bases obtained through the condensation of 4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one (AAP) with ohidroxybenzaldehyde (SAL), terephthalic aldehyde (TA), 2-hidroxy-3-metoxy-izofthalaldehyde (FV), 2,3-dihidroxy-izofthalaldehyde (DHV) respectively. The characterization of the newly formed complexes was done by 1H RMN, UV-VIS, IR and RES spectroscopy, thermal derivatographic analysis and molar electric conductibility. The RES spectrum for the complex combination [Cu(C18H16N3O2)(H2O)]Cl, as a powder, at room temperature, indicates values of tensor{g} confirming the symmetry C2v of the Cu2+ pentacoordinated ion. For the low symmetry Cu(II) ions, the fundamental state for the paramagnetic electron is not described by a single d function, but there is a mixture of them. The mixtures degree of these functions increases as the symmetry decreases. The high values of the {g} tensor confirm low symmetry. The RES spectra for the complex combination [Cu2(C30H28N6O2)(SO4)2] as a powder, at room temperature, with values of the {g} tensor, g1 = 2,088 and g2 = 2,446, confirms the Td symmetry. As it is noticed, the spectrum does not present interactions that might indicate a hyperfine structure. The lack of the hyperfine structure or the presence of very small hyperfine splitting for the Cu2+ ion in Td symmetry, or lower symmetry were explained by C.A. Bates et all, by mixing the 4pz orbital of the metallic ion with the 3dxy orbital defining the fundamental state. The determination of the anti-microbial activity of the ligands and of the complex combinations was realized on stems of Escherichia coli, Klebsiella pneumoniae, Acinetobacter boumanii, Pseudomonas aeruginosa, Staphylococcus aureus and Candida sp. The results of the qualitative and quantitative testing of the anti-microbial activity proved that all prepared combinations are very active especially when in contact with the stems of Ps. aeruginosa, A. Boumanii, E. coli and S. aureus.