Ulcere gigante sunt cele cu diametrul mai mare de 2,53 cm şi cu pierderi de substanţă de mari dimensiuni. Ele sunt caracterizate printr-o localizare predominant gastrică mai frecvent pe curbura mică a stomacului, simptoame specifice şi cel mai frecvent sunt asociate cu hemoragie, perforaţie şi stenoze, complicaţii severe fără a răspunde la tratamentul standard medical. Cele mai multe ulcere gigante necesită tratament chirurgical.

Giant ulcers are ulcers over 2.53 cm in diameter and with great substance loss. They are characterized by a predominantly gastric location, most commonly at the level of the lesser gastric curvature, particular symptoms, and are most frequently associated with hemorrhage, perforations and stenoses, complications the more severe as they do not respond to the standard medical treatment. Most giant ulcers require surgery.