Copper (II) salts form with thiosemicarbazones and 4-phenilthiosemicarbazones
(L) of 5-chloro-, 5-bromo-, 5-nitro-, 5-methyl-, 3.5dichloro-,
3.5-dibromo- and 3,5–dinitrosalycil aldehydes different compounds of general
formulae Cu(L-H)X ⋅ nH2O, Cu(L-2H) ⋅ nH2O and CuA (L-2H) ⋅ H2O (X = Cl, Br,
NO3
,1/2 SO4; A = NH3, C5H5N, 2-, 3-, 4-CH3C5H4N, 2-, 3-, 4-NH2C5H4N; n = 0-5).
It has been established that the synthesized complex compounds have
selective bacteriostatic and bactericide activity towards 12 standard stamps of
staphylococcus, streptococcus and intestinal bacilli in the concentration range
0,009-300μg/ml [1]. The main influence on the antimicrobial properties is caused
by the nature and position of the substitute in the benzene ring, of the ligand
salicylic fragment and in case of the compounds having analogous composition,

the activity changes in the following order : 3,5-dibromo- > 3,5-chloro- > 5-
bromo- > 5-chloro- > 5-nitro- > 5-methyl-. The minimal suppressing and
bactericide concentrations of the compounds are as well affected by the nature
of the internal acid fragment: having the same substitute in the azomethine,
the highest activity is displayed by the bromide containing complexes, and the
lowest - by the chloride analogues.
Some of the obtained coordination compounds have also cancer static effect
inhibiting the growth of myeloid leukemia and prostate sells in the concentration
range 10-6 -10-7 mol/l.
The researches have been performed with financial support of projects
3C28, PAS AUF 2001/24.
References
1. Prisacari V., Ţapcov V., Buraciov S., Bărcă M., Gulea A. Brevet de invenţie
MD nr. 2003. Publ. BOPI nr. 9. 2002