Synthesis, antimicrobial and anticancer properties of copper (II) coordination compounds with thiosemicarbazones of substituted ortohydroxibenzaldehydes
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GULEA, Aurelian; PRISAKARI, Viorel I.; POIRIER, Donald; BEJENARI, Natalia; BURACIOVA, Svetlana; ROY, Jenny; BÎRCĂ, Maria; TSAPKOV, Victor. Synthesis, antimicrobial and anticancer properties of copper (II) coordination compounds with thiosemicarbazones of substituted ortohydroxibenzaldehydes. In: Чугаевская конференция по координационной химии. 20-24 iunie 2005, Chişinău. Chișinău, Republica Moldova: Tipografia Academiei de Ştiinţe a Moldovei, 2005, pp. 237-238.
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Чугаевская конференция по координационной химии 2005
Conferința "Чугаевская конференция по координационной химии"
Chişinău, Moldova, 20-24 iunie 2005

Synthesis, antimicrobial and anticancer properties of copper (II) coordination compounds with thiosemicarbazones of substituted ortohydroxibenzaldehydes


Pag. 237-238

Gulea Aurelian1, Prisakari Viorel I.2, Poirier Donald3, Bejenari Natalia1, Buraciova Svetlana2, Roy Jenny3, Bîrcă Maria1, Tsapkov Victor1
 
1 State University of Moldova,
2 ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
3 Universitatea Laval
 
Disponibil în IBN: 28 mai 2020



Teza

Copper (II) salts form with thiosemicarbazones and 4-phenilthiosemicarbazones
(L) of 5-chloro-, 5-bromo-, 5-nitro-, 5-methyl-, 3.5dichloro-,
3.5-dibromo- and 3,5–dinitrosalycil aldehydes different compounds of general
formulae Cu(L-H)X ⋅ nH2O, Cu(L-2H) ⋅ nH2O and CuA (L-2H) ⋅ H2O (X = Cl, Br,
NO3
,1/2 SO4; A = NH3, C5H5N, 2-, 3-, 4-CH3C5H4N, 2-, 3-, 4-NH2C5H4N; n = 0-5).
It has been established that the synthesized complex compounds have
selective bacteriostatic and bactericide activity towards 12 standard stamps of
staphylococcus, streptococcus and intestinal bacilli in the concentration range
0,009-300μg/ml [1]. The main influence on the antimicrobial properties is caused
by the nature and position of the substitute in the benzene ring, of the ligand
salicylic fragment and in case of the compounds having analogous composition,

the activity changes in the following order : 3,5-dibromo- > 3,5-chloro- > 5-
bromo- > 5-chloro- > 5-nitro- > 5-methyl-. The minimal suppressing and
bactericide concentrations of the compounds are as well affected by the nature
of the internal acid fragment: having the same substitute in the azomethine,
the highest activity is displayed by the bromide containing complexes, and the
lowest - by the chloride analogues.
Some of the obtained coordination compounds have also cancer static effect
inhibiting the growth of myeloid leukemia and prostate sells in the concentration
range 10-6 -10-7 mol/l.
The researches have been performed with financial support of projects
3C28, PAS AUF 2001/24.
References
1. Prisacari V., Ţapcov V., Buraciov S., Bărcă M., Gulea A. Brevet de invenţie
MD nr. 2003. Publ. BOPI nr. 9. 2002