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SM ISO690:2012 PÂNTEA, Victor. Efectele adverse ale terapiei antivirale în hepatita virală C cronică și managementul lor. In: Sănătate Publică, Economie şi Management în Medicină , 2012, nr. 5(44), pp. 34-37. ISSN 1729-8687. |
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Sănătate Publică, Economie şi Management în Medicină | |||||
Numărul 5(44) / 2012 / ISSN 1729-8687 /ISSNe 2587-3873 | |||||
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Pag. 34-37 | |||||
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Viral hepatitis C is a public health problem. Acute forms occur in 20% of cases, while the rest of them develop having asymptomatic forms. Recovery occurs in 10-30% of cases, while the rest have a chronic evolution, occuring in 50-60% of cases, developing cirrhosis in 18-20 years and hepatocarcinoma in 26-28 years. It is well known that elective therapy is the antiviral combined with interferons and ribavirin which cause adverse effects. The most frequent are: fatigue, fever, mialgias, athralgias, and less frequent are: depression, thyroidal diseas, interstitial pneumonia, vitiligo, psoriasis, loss of hair. As a rule, hematological side effects like anemia are a consequence of treatment with ribavirin, while neutropenia and thrombocytopenia, of interferonic therapy. Severe anemia is treated with erythropoetin, while neutropenia with fi lgastreme. Our trials determined (84 patients were treated with pegasys and copegus) the following side effects: local-hypermia – 17,9%; early side effects: fever – 73,2%; headaches – 47,3%; late side effects: loss of hair – 22,4%. Hematological side effects: anemia – 31,3% leucopenia – 35,8%; thrombocytopenia – 23,9%. Anemia was treated with medicines containing iron, while leucopenia with homeopatics – cytomix and lymphomyosot. |
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Cuvinte-cheie viral hepatitis C, antiviral therapy, side effects, Anemia, neutropenia, erythropoetin, filgastreme., вирусный гепатит С, побочные эффекты, противовирусная терапия, анемия, нейтропения, эритропоетин, филграстим |
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