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| Ultima descărcare din IBN: 2022-11-03 15:47 |
 SM ISO690:2012BAUL, Bianca Beatrice, ŞUTA, Lenuţa-Maria, DRAGOMIRESCU, Anca, MUNTEAN, Cornelia, LEDEŢI, Adriana, VLASE, Gabriela, VLASE, Titus, MUREȘAN, Cezara, LEDEŢI, Ionuţ. Preformulation studies for mycophenolic acid for solid dosage forms. In: Book of Abstracts: of the 28th Symposium on Thermal Analysis and Calorimetry – Eugen Segal – of the Commission for Thermal Analysis and Calorimetry of the Romanian Academy (CATCAR28), Ed. 28, 9-10 mai 2019, Chişinău. România, Arad: Gutenberg Univers Arad Publishing House, 2019, p. 34. ISBN 978-606-675-208-4. |
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| Book of Abstracts 2019 | |
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Simpozionul "28th Symposium on Thermal Analysis and Calorimetry – Eugen Segal – of the Commission for Thermal Analysis and Calorimetry of the Romanian Academy (CATCAR28) " 28, Chişinău, Moldova, 9-10 mai 2019 | |
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| Pag. 34-34 | |
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Mycophenolic acid (MPA) is a commonly used immunosuppressive medication, conditioned as acid form, as sodium salt or as prodrug, mycophenolate mofetil. MPA is used for the prevention of organ transplant rejection in adults and renal transplant rejection in children older than two years [1]. There are several pharmaceutical solid dosage forms containing MPA on Romanian market, with strengths of 180 or 360 mg per tablet [2]. In this study, we evaluated the compatibility of MPA with ten common pharmaceutical excipients, namely starch, microcrystalline cellulose, lactose, calcium lactate, mannitol, PVP, SiO2, sorbitol, magnesium stearate and talc, using as investigational tools thermal analysis in dynamic air atmosphere (TG/DTG/HF data), FTIR spectroscopy and PXRD patterns |
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