Quadriceps retraction after intramuscular injections requires a great attention, considering the fact that it causes a serious disability. The condition appears in children born prematurely or underweight that were hospitalized for a long time during the neo- natal period and in the first years of life. The knee‟s stiffness represents a surgical illness, but the general practioner (GP) has the duty to prevent it. The GP should be aware of the risk the intra-muscular injections have in new-born and disabled children(1,8,9). If, still, the disease has been identified and clinical signs are present, the pediatricians and family physicians have the duty to guide the earlier treatment of these children in a department of pediatric surgery and orthopedics. Also, after being discharged from surgical departments, family physicians and pediatricians must pursue their rehabilitation for a long time because the post-operative evolution can be difficult, walking again can cause many problems, complications can occur, and relapses. It is very important to be familiar with this disease in pediatric practice. The topic is of out most interest for the pharmaceutical industry because it brings forward the issue of creating new drugs to be administered by routes other than intramuscular one, but with the same efficiency and tolerance.