Synthesis, structure and biological properties of copper(II) coordination compounds with quinoline 4-substituted thiosemicarbazone
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STRATULAT, Elena, BOUROSH, Pavlina, KORZHA, I., PUI, Aurel, DIZDARI, Anna, PRISAKARI, Viorel I., PALAMARCIUC, Oleg. Synthesis, structure and biological properties of copper(II) coordination compounds with quinoline 4-substituted thiosemicarbazone. In: Physical Methods in Coordination and Supramolecular Chemistry, 8-9 octombrie 2015, Chişinău. Chisinau, Republic of Moldova: 2015, XVIII, p. 144.
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Physical Methods in Coordination and Supramolecular Chemistry
XVIII, 2015
Conferința ""Physical Methods in Coordination and Supramolecular Chemistry""
Chişinău, Moldova, 8-9 octombrie 2015

Synthesis, structure and biological properties of copper(II) coordination compounds with quinoline 4-substituted thiosemicarbazone


Pag. 144-144

Stratulat Elena1, Bourosh Pavlina2, Korzha I.1, Pui Aurel3, Dizdari Anna4, Prisakari Viorel I.4, Palamarciuc Oleg1
 
1 Moldova State University,
2 Institute of Applied Physics,
3 Alexandru Ioan Cuza University of Iaşi,
4 ”Nicolae Testemițanu” State University of Medicine and Pharmacy
 
Disponibil în IBN: 22 aprilie 2020


Rezumat

Thiosemicarbazones are currently well established as an important class of sulphur donor ligands particularly for transition metal ions. Thiosemicarbazones and their metal complexes have received considerable attention because of their antifungal, antibacterial, anti-inflammatory, antiviral and antitumor activities [1, 2]. Interest cooper(II) complexes with 8-formylquinoline thiosemicarbazone derivatives has been stimulated because that their biological activities are often enhanced on complexation [3]. Two compounds with the general formula Cu(HL)(NO3)2·nH2O obtained in reaction of Cu(NO3)2·3H2O with corresponding organic ligands (HL1- 4-[2,3-dimethylphenyl]thiosemicarbazone 8-formylquinoline (1) and HL2-4-[2,4-dimethylphenyl]thiosemicarbazone 8-formylquinoline (2)) were separated and structurally characterized. Single crystals suitable for X-ray diffraction studies were obtained by slow evaporation of the solvent from an aqueous solution of the product at room temperature. X-ray analisys shows a mononuclear structure of the products. The copper(II) metal ions are coordinated hexadentate - NNS from organic ligands, two water molecues and one oxygen from nitro anion.figureFig. 1. Crystal structure of the compound 1 (left) and 2 (right). The antimicrobial activities of the complexes were evaluated. The antimicrobial activity are superior with reference furaciline - compound.