Synthesis and antitumor properties of derivatives 4-substituted-5-(piridin-4-yl)-4h-1,2,4-triazole-3-thiol
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RUSNAC, Roman, ZATIC, Ana, PAHOLNITSCAIA, Anastasia, BARBA, Nicanor, PERREAULT, M., GULYA, Aurelian. Synthesis and antitumor properties of derivatives 4-substituted-5-(piridin-4-yl)-4h-1,2,4-triazole-3-thiol. In: Physical Methods in Coordination and Supramolecular Chemistry, 8-9 octombrie 2015, Chişinău. Chisinau, Republic of Moldova: 2015, XVIII, p. 131.
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Physical Methods in Coordination and Supramolecular Chemistry
XVIII, 2015
Conferința ""Physical Methods in Coordination and Supramolecular Chemistry""
Chişinău, Moldova, 8-9 octombrie 2015

Synthesis and antitumor properties of derivatives 4-substituted-5-(piridin-4-yl)-4h-1,2,4-triazole-3-thiol


Pag. 131-131

Rusnac Roman1, Zatic Ana1, Paholnitscaia Anastasia1, Barba Nicanor1, Perreault M.2, Gulya Aurelian1
 
1 Moldova State University,
2 CHUL Research Center (Université Laval)
 
Disponibil în IBN: 22 aprilie 2020


Rezumat

In recent years, the chemistry of triazoles and their fused heterocyclic derivatives has received considerable attention owing to their synthetic and effective biological importance [1]. Literature survey reveals that 1,2,4-triazole derivatives exhibit a wide range of biological activities including Antibacterial, Antifungal, Antitumour, Anti-inflammatory, Antitubercular, Hypoglycemic, Antidepressant, Anticonvulsant, Anticancer, Antimalarial, Antiviral, Antiproliferative, Analgesic and Antimigraine [1,2]. The derivatives of 4-substituted-5(piridin-4-yl)-4H-1,2,4-triazole-3-thiol were synthesized according to scheme:schemeTable. The antiproliferative activity of 4-substituted-5-(piridin-4-yl)-4H-1,2,4-triazole-3-thiol on human on leukemia (HL-60) cells.tableThe obtained data demonstate that the synthesized compounds show moderate (3-11%) antiproliferative activity. Compounds e and d were tested on melanoma (MeW-164) and on human leukemia (HL-60) cells, in the range of (0,1-10 μM) concentrations. The results proved thait they have a higher (16-23%) antiproliferative activity. 

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<dc:creator>Rusnac, R.</dc:creator>
<dc:creator>Zatic, A.</dc:creator>
<dc:creator>Paholniţcaia, A.</dc:creator>
<dc:creator>Barbă, N.</dc:creator>
<dc:creator>Perreault, M.</dc:creator>
<dc:creator>Gulea, A.P.</dc:creator>
<dc:date>2015</dc:date>
<dc:description xml:lang='en'><p>In recent years, the chemistry of triazoles and their fused heterocyclic derivatives has received considerable attention owing to their synthetic and effective biological importance [1]. Literature survey reveals that 1,2,4-triazole derivatives exhibit a wide range of biological activities including Antibacterial, Antifungal, Antitumour, Anti-inflammatory, Antitubercular, Hypoglycemic, Antidepressant, Anticonvulsant, Anticancer, Antimalarial, Antiviral, Antiproliferative, Analgesic and Antimigraine [1,2]. The derivatives of 4-substituted-5(piridin-4-yl)-4H-1,2,4-triazole-3-thiol were synthesized according to scheme:</p><p>scheme</p><p>Table. The antiproliferative activity of 4-substituted-5-(piridin-4-yl)-4H-1,2,4-triazole-3-thiol on human on leukemia (HL-60) cells.</p><p>table</p><p>The obtained data demonstate that the synthesized compounds show moderate (3-11%) antiproliferative activity. Compounds e and d were tested on melanoma (MeW-164) and on human leukemia (HL-60) cells, in the range of (0,1-10 &mu;M) concentrations. The results proved thait they have a higher (16-23%) antiproliferative activity.</p><p>&nbsp;</p></dc:description>
<dc:source>Physical Methods in Coordination and Supramolecular Chemistry (XVIII) 131-131</dc:source>
<dc:title>Synthesis and antitumor properties of derivatives 4-substituted-5-(piridin-4-yl)-4h-1,2,4-triazole-3-thiol</dc:title>
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