Synthesis and antitumor properties of derivatives 4-substituted-5-(piridin-4-yl)-4h-1,2,4-triazole-3-thiol
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RUSNAC, Roman; ZATIC, Ana; PAHOLNITSCAIA, Anastasia; BARBA, Nicanor; PERREAULT, M.; GULEA, Aurelian. Synthesis and antitumor properties of derivatives 4-substituted-5-(piridin-4-yl)-4h-1,2,4-triazole-3-thiol. In: Physical Methods in Coordination and Supramolecular Chemistry. XVIII, 8-9 octombrie 2015, Chişinău. Chisinau, Republic of Moldova: 2015, p. 131.
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Physical Methods in Coordination and Supramolecular Chemistry
XVIII, 2015
Conferința ""Physical Methods in Coordination and Supramolecular Chemistry""
Chişinău, Moldova, 8-9 octombrie 2015

Synthesis and antitumor properties of derivatives 4-substituted-5-(piridin-4-yl)-4h-1,2,4-triazole-3-thiol


Pag. 131-131

Rusnac Roman1, Zatic Ana1, Paholnitscaia Anastasia1, Barba Nicanor1, Perreault M.2, Gulea Aurelian1
 
1 State University of Moldova,
2 CHUL Research Center (Université Laval)
 
Disponibil în IBN: 22 aprilie 2020


Rezumat

In recent years, the chemistry of triazoles and their fused heterocyclic derivatives has received considerable attention owing to their synthetic and effective biological importance [1]. Literature survey reveals that 1,2,4-triazole derivatives exhibit a wide range of biological activities including Antibacterial, Antifungal, Antitumour, Anti-inflammatory, Antitubercular, Hypoglycemic, Antidepressant, Anticonvulsant, Anticancer, Antimalarial, Antiviral, Antiproliferative, Analgesic and Antimigraine [1,2]. The derivatives of 4-substituted-5(piridin-4-yl)-4H-1,2,4-triazole-3-thiol were synthesized according to scheme:schemeTable. The antiproliferative activity of 4-substituted-5-(piridin-4-yl)-4H-1,2,4-triazole-3-thiol on human on leukemia (HL-60) cells.tableThe obtained data demonstate that the synthesized compounds show moderate (3-11%) antiproliferative activity. Compounds e and d were tested on melanoma (MeW-164) and on human leukemia (HL-60) cells, in the range of (0,1-10 μM) concentrations. The results proved thait they have a higher (16-23%) antiproliferative activity.