Articolul precedent |
Articolul urmator |
634 7 |
Ultima descărcare din IBN: 2022-12-08 09:04 |
SM ISO690:2012 PAKHONTSU, E., PARASCHIVESCU, Codruța, ILIES, D., POIRIER, Donald, OPREAN, Camelia, GULYA, Aurelian, ROSHU, T.. Synthesis, characterization and biological activity of novel CU(II), PD(II), PT(II) complexes with 2-hydroxy-8-ethyltricyclo[7.3.1.0.2,7]tridecane-13-one thiosemicarbazone. In: Physical Methods in Coordination and Supramolecular Chemistry, 8-9 octombrie 2015, Chişinău. Chisinau, Republic of Moldova: 2015, XVIII, p. 114. |
EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
Physical Methods in Coordination and Supramolecular Chemistry XVIII, 2015 |
|
Conferința ""Physical Methods in Coordination and Supramolecular Chemistry"" Chişinău, Moldova, 8-9 octombrie 2015 | |
|
|
Pag. 114-114 | |
Descarcă PDF | |
Rezumat | |
The chemistry of transition metal complexes of thiosemicarbazones have gained considerable attention due to their diverse applications in the pharmacological field as antimicrobial agents [1- 4] and found to have in vitro cytotoxic effects against cancer cells [5]. In this research, we have synthesized and characterized new Cu(II), Pd(II) and Pt(II) complexes: [Cu(L)(H2O)2(OAc)](1),[Cu(L)(H2O)2(SO4)](2),[Cu(L)(H2O)2(NO3)](3),[Cu(L)(H2O)2(ClO4)](4), [Cu(L)2(H2O)2] (5), [Pd(L)(OAc)]H2O (6), [Pt(L)2] (7) were HL= 2-hydroxy-8-ethyl-tricyclo [7.3.1.0.2,7]tridecane-13-one-thiosemicarbazone. The ligand has been characterized by elemental analyses, IR, 1H NMR and 13C NMR spectroscopy, mass spectroscopy. All complexes have been characterized by IR, 1H NMR, 13C NMR, UV-Vis, FAB, EPR, mass spectroscopy, elemental and thermal analysis, magnetic susceptibility measurements and molar electric conductivity. The physico-chemical analyses confirmed the composition and the structure of the newly obtained complex combinations. All complexes with 2-hydroxy-8-R-tricyclo[7.3.1.0.2,7]tridecane-13-one thiosemicarbazone have been tested for their antimicrobial activity against Escherichia coli, Salmonella enteritidis, Staphylococcus aureus, Enterococcus, Candida albicans and cytotoxicity against SKBR-3 human breast, MCF-7 human breast, A375 human melanoma cancer cells and HL-60 human promyelocytic leukemia cells. |
|
|
DataCite XML Export
<?xml version='1.0' encoding='utf-8'?> <resource xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xmlns='http://datacite.org/schema/kernel-3' xsi:schemaLocation='http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd'> <creators> <creator> <creatorName>Pahontu, E.</creatorName> <affiliation>Universitatea de Medicină şi Farmacie „Carol Davila“, România</affiliation> </creator> <creator> <creatorName>Paraschivescu, C.</creatorName> <affiliation>Universitatea din Bucureşti, România</affiliation> </creator> <creator> <creatorName>Ilies, D.</creatorName> <affiliation>Universitatea din Bucureşti, România</affiliation> </creator> <creator> <creatorName>Poirier, D.</creatorName> <affiliation>CHU de Quebec – Research Center (CHUL, T4), Canada</affiliation> </creator> <creator> <creatorName>Oprean, C.</creatorName> <affiliation>Universitatea de Medicină şi Farmacie „Victor Babes“, Timişoara, România</affiliation> </creator> <creator> <creatorName>Gulea, A.P.</creatorName> <affiliation>Universitatea de Stat din Moldova, Moldova, Republica</affiliation> </creator> <creator> <creatorName>Roşu, T.</creatorName> <affiliation>Universitatea din Bucureşti, România</affiliation> </creator> </creators> <titles> <title xml:lang='en'>Synthesis, characterization and biological activity of novel CU(II), PD(II), PT(II) complexes with 2-hydroxy-8-ethyltricyclo[7.3.1.0.2,7]tridecane-13-one thiosemicarbazone</title> </titles> <publisher>Instrumentul Bibliometric National</publisher> <publicationYear>2015</publicationYear> <relatedIdentifier relatedIdentifierType='ISBN' relationType='IsPartOf'></relatedIdentifier> <dates> <date dateType='Issued'>2015</date> </dates> <resourceType resourceTypeGeneral='Text'>Conference Paper</resourceType> <descriptions> <description xml:lang='en' descriptionType='Abstract'><p>The chemistry of transition metal complexes of thiosemicarbazones have gained considerable attention due to their diverse applications in the pharmacological field as antimicrobial agents [1- 4] and found to have in vitro cytotoxic effects against cancer cells [5]. In this research, we have synthesized and characterized new Cu(II), Pd(II) and Pt(II) complexes: [Cu(L)(H2O)2(OAc)](1),[Cu(L)(H2O)2(SO4)](2),[Cu(L)(H2O)2(NO3)](3),[Cu(L)(H2O)2(ClO4)](4), [Cu(L)2(H2O)2] (5), [Pd(L)(OAc)]H2O (6), [Pt(L)2] (7) were HL= 2-hydroxy-8-ethyl-tricyclo [7.3.1.0.2,7]tridecane-13-one-thiosemicarbazone. The ligand has been characterized by elemental analyses, IR, 1H NMR and 13C NMR spectroscopy, mass spectroscopy. All complexes have been characterized by IR, 1H NMR, 13C NMR, UV-Vis, FAB, EPR, mass spectroscopy, elemental and thermal analysis, magnetic susceptibility measurements and molar electric conductivity. The physico-chemical analyses confirmed the composition and the structure of the newly obtained complex combinations. All complexes with 2-hydroxy-8-R-tricyclo[7.3.1.0.2,7]tridecane-13-one thiosemicarbazone have been tested for their antimicrobial activity against Escherichia coli, Salmonella enteritidis, Staphylococcus aureus, Enterococcus, Candida albicans and cytotoxicity against SKBR-3 human breast, MCF-7 human breast, A375 human melanoma cancer cells and HL-60 human promyelocytic leukemia cells.</p></description> </descriptions> <formats> <format>application/pdf</format> </formats> </resource>