Polymers in supramolecular assemblies for bio-related applications
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2020-11-20 14:32
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SIMIONESCU, Bogdan. Polymers in supramolecular assemblies for bio-related applications. In: Physical Methods in Coordination and Supramolecular Chemistry, 8-9 octombrie 2015, Chişinău. Chisinau, Republic of Moldova: 2015, XVIII, p. 2.
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Physical Methods in Coordination and Supramolecular Chemistry
XVIII, 2015
Conferința ""Physical Methods in Coordination and Supramolecular Chemistry""
Chişinău, Moldova, 8-9 octombrie 2015

Polymers in supramolecular assemblies for bio-related applications


Pag. 2-2

Simionescu Bogdan
 
“Petru Poni” Institute of Macromolecular Chemistry
 
Disponibil în IBN: 17 aprilie 2020


Rezumat

Last decades, a pronounced need for new materials for biomedical application, able to provide more efficient treatments and to insure minimization of the side effects, to increase patient compliance and satisfaction is evident. At the same time, advances in polymer science have led to the development of several novel systems designed for drug/gene delivery and tissue engineering, areas with pivotal role for both research/academic community and industry, generating new niche markets. In this respect, recent years have witnessed an increased interest in the rational design of complex polymeric structures. The main objectives are related to the development of tailored polymer materials, engineered to exert distinct biological functions, implying multifunctionality as well as appropriate form/architectural features, giving rise to specificity and high responsiveness. To gain further clinical importance the new materials must provide not only high physicochemical and biological performances but also processing ability. These demands – and especially the last one – often imply combination of natural and synthetic polymers (blends, block/graft copolymers, bioconjugates, interpenetrating networks, etc.), while improved performances may be mainly achieved by composite materials (inorganic/organic, biocomposites). The targeted application site or cargo may require specific material category (biodegradable, bioresorbable), dimension scale (micro/nano size) and topographic characteristics. Some of the existing essential obstacles and limitations may be surpassed by combining systems and approaches from apparently different application domains. Thus, controlled drug delivery and its application in tissue engineering for tissue growth support and stimulation attracted much attention over the last decade, while combination of gene therapy and tissue engineering within a single system resulting in a powerful synergism of treatment options for regenerative medicine (scaffold mediated gene therapy) seems to be the favored alternative for tissue healing. The presentation summarizes the history and challenges in the discussed domains, pointing on polymers as a possible solution to specific challenges, and outlines the current state of the art, focusing on the newest strategies to improve systems effectiveness and responsiveness (design keys, preparative approaches). Expected future directions are underlined. Acknowledgement. This work was financially supported by the Romanian National Authority for Scientific Research, CNCS - UEFISCDI, project PN-II-ID-PCCE-2011-2-0028.