The era of globalization involves interactions and inter-state and inter-human relations of all types, including economic ones. An important place among them also belongs to the cross-border ones. The paradigm is the model, the dominant aspect in science and the knowledge of a certain period of time or epoch. There are particular paradigms, specific to one or another science, to one or another domain. There are also general or universal paradigms, such as ecological and communication ones. The human paradigm is, however, the most universal one, as it manifests itself in all spheres and fields of human activity and practice, including economics. The whole practice and knowledge, according to the universal paradigm of humanity, must be directed towards ensuring the security and survival of humans, society and nature. The true human is the person with a high and permanent morality and moral behavior. Namely, Man is the supreme value for man and for this reason today, while being in danger, he has become the most important global problem, which practically includes in itself all other problems. The universal paradigm of humanity is compulsory even for the fields of medicine, military and force spheres. It occupies a special place in the real economy and economic science.