Antioxidant activity of spirulina biomass at the action of some pegilated nanoparticles
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2024-01-30 09:38
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RUDI, Ludmila, CEPOI, Liliana, CHIRIAC, Tatiana, ROTARI, Ion, PLÂNGĂU, Dinu, VALUŢĂ, Ana, CARAUŞ, Vladimir, RUDIC, Valeriu. Antioxidant activity of spirulina biomass at the action of some pegilated nanoparticles. In: Life sciences in the dialogue of generations: connections between universities, academia and business community, Ed. 1, 21-22 octombrie 2019, Chişinău. Chișinău, Republica Moldova: Tipogr. "Biotehdesign", 2019, pp. 71-72.
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Life sciences in the dialogue of generations: connections between universities, academia and business community 2019
Conferința "Life sciences in the dialogue of generations: connections between universities, academia and business community"
1, Chişinău, Moldova, 21-22 octombrie 2019

Antioxidant activity of spirulina biomass at the action of some pegilated nanoparticles


Pag. 71-72

Rudi Ludmila1, Cepoi Liliana1, Chiriac Tatiana1, Rotari Ion2, Plângău Dinu2, Valuţă Ana1, Carauş Vladimir2, Rudic Valeriu1
 
1 Institutul de Microbiologie şi Biotehnologie,
2 Universitatea de Stat „Dimitrie Cantemir”
 
Disponibil în IBN: 10 decembrie 2019


Rezumat

Microalgae are recognized sources of substances with antiradical and antioxidant properties. They are used as raw material for obtaining natural preservatives and pharmaceutical preparations. In recent times, microalgae successfully compete with traditional monocomponent plant sources of antioxidants. Their protection systems are very dynamic, responding promptly to environmental changes and physiological state by modifying the intensity of antioxidant properties. One of the main factors, which essentially modifies the antioxidant status of aquatic organisms, is the presence of metals in the environment. Understanding of the mechanisms involved in eliciting their action on the antioxidant status of microalgae ensures the possibility of obtaining a biomass, which contains a synergistic complex of antioxidant and antiradical substances. Highlighting the mechanisms for modeling the antioxidant status of spirulina, as well as increasing the quantity of substances with antioxidant and antiradical properties by using different principles of directing the biotechnological processes, offer the possibility to predict the quality of obtained biomass. Altering the antioxidant activity of spirulina biomass, in the direction of increase or reduction, is the result of toxic action of xenobiotics on spirulina culture. High concentrations of xenobiotics reduce the antioxidant activity of ethanolic extracts obtained from spirulina biomass.  The action of AgPEGNPs (5nm), AuPEGNPs (5nm), CuPEGNPs (5nm) and CdPEGNPs (5nm) has been studied. High concentrations (1.0-10.0 μM/L) of AgPEGNPs and AuPEGNPs cause a reduction of the antioxidant activity of ethanolic extracts obtained from spirulina biomass with 40-54% and 35-57%, respectively.ABTS assay for ethanolic extracts from biomass, grown in the presence of CuPEGNPs, also established a reduction in antioxidant activity for high concentrations of these nanoparticles. Cadmium nanoparticles in low concentrations did not alter the antioxidant activity of extracts, which may be the result of the absence of a toxic effect of nano-scale cadmium. ABTS test for hydric extracts obtained from biomass, cultivated in the presence of AgPEGNPs, established an increase of antioxidant values by 38% at 10.0 μM concentration of these nanoparticles. In the case of applying AuPEGNPs, the antioxidant activity of hydric extracts from spirulina biomass has not changed. ABTS test for hydric extracts from biomass, grown in the presence of CuPEGNPs, established an increase of antioxidant values with 29-53% in the case of their adding in concentrations of 1.25-3.75 μM/L. High concentrations of CdPEGNPs did not alter the antioxidant activity of hydric extracts from spirulina biomass. In the case of applying CdPEGNPs, no toxic effect has been established. Therefore, the action of nanoparticles, used as stimulators of biosynthetic activity of spirulina, was not the result of induced stress.