The results of studies obtained on the basis of long-term stationary and time experience, the impact of the main application of mineral nitrogen and timing of nitrogen fertilizing on the yield and quality of winter wheat in the South of Ukraine on the southern chernozem. It is shown that the transfer of 50% of the dose of mineral nitrogen to the fertilizing in spring tillering has no significant advantage over the main application of the entire dose as part of a complete mineral fertilizer. The share of influence of the predecessor and fertilizer systems on the level of winter wheat harvest is 14% and 17%, respectively; the formation of the same quality indicators as the content of protein and gluten, 36% and 41% determined fertilizers; predecessors and fractional application of mineral nitrogen by type : 50% - the main application, 50% - spring tillering - 4-3%. Noted that feeding N90 background Р60К60 when growing winter wheat winter rapeseed increases the yield when autumn introduction by 28.9 and 30.5%, and with from January until spring Kasenna – 37.540,2%. The protein content in grain increased by 14.7% in comparison with the background Р60К60 at provedeni dressing at the beginning of stem elongation; hardness of grain above the control background option in almost all periods of feeding.