An evaluation of the structure, thermal behaviour and kinetic parameters of a novel biomimetic hybrid organic/inorganic hydroxyapatite-based composite
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ALBU, Paul, SERBAN, Iren Andrea, GEICU, Ovidiu, STANCA, Loredana, STANCIU, Alexandra, MATEESCU, Madalina, VLASE, Gabriela, VLASE, Titus. An evaluation of the structure, thermal behaviour and kinetic parameters of a novel biomimetic hybrid organic/inorganic hydroxyapatite-based composite. In: Central and Eastern European Conference on Thermal Analysis and Calorimetry, Ed. 4, 28-31 august 2017, Chişinău. Germany: Academica Greifswald, 2017, Editia 4, p. 236. ISBN 978-3-940237-47-7.
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Central and Eastern European Conference on Thermal Analysis and Calorimetry
Editia 4, 2017
Conferința "Central and Eastern European Conference"
4, Chişinău, Moldova, 28-31 august 2017

An evaluation of the structure, thermal behaviour and kinetic parameters of a novel biomimetic hybrid organic/inorganic hydroxyapatite-based composite


Pag. 236-236

Albu Paul12, Serban Iren Andrea3, Geicu Ovidiu3, Stanca Loredana3, Stanciu Alexandra2, Mateescu Madalina1, Vlase Gabriela1, Vlase Titus1
 
1 West University of Timisoara,
2 “Vasile Goldis” Western University of Arad,
3 University of Agronomical Sciences and Veterinary Medicine Bucharest
 
 
Disponibil în IBN: 30 septembrie 2019


Rezumat

Bioceramics like hydroxyapatite (HA) and other calcium phosphates cements (CPC) attract great interest in the field of bone tissue restoration due to their excellent biocompatibility, bioactivity, bone reggeneration ability, osteoconductivity [1, 2] and chemical bone-binding properties [3]. Although CPC possess high tissue compatibility, the restriction of their use is their brittle nature, poor mechanical strength, lack of macroporosity, low porosity degree responsible for their slow resorbtion rate [1] and a low rate of osseointegration with bone tissues [3]. Due to the unique organic-inorganic composite structure of osseous tissue, design strategies in vitro aim to mimic the natural mineralization process [4]. Therefore, a composite biomaterial of HA and natural or synthetic biocompatible and biodegradable polymers is expected to show not only an increased osteoconductivity, osseointegration and biodegradation properties but also sufficient mechanical strength. For this current study, we developed a new biomimetic HA-based composite by mixing, under proper reaction conditions, the inorganic precursors of the mineral bone-like structure and a carrageenan aqueous solution used to provide the organic matrix employed as template for the HA crystal growth. Samples of the organic/inorganic hybrid material were characterized before and after the sinterization process by FTIR, XRD, SEM and EDAX analysis.TG/DTG/HF analysis was performed on the biomimetic hydroxyapatite composite in order to determine the thermal behaviour of the hybrid material. The thermoanalytical data were recorded using five heating rates, β = 7, 10, 12, 15 and 20 °C·min-1, in air atmosphere and they were further used to determine the kinetic parameters of the main degradation process. All the kinetic methods used in this study, were isoconversional according to ICTAC 2000 Protocol, using Kissinger-Akahira-Sunose, Flynn-WallOzawa and the modified NPK methods to estimate the activation energy of the studied process. 4000.0 3600 3200 2800 2400 2000 1800 1600 1400 1200 1000 800 650.0 47.9 50 52 54 56 58 60 62 64 66 68 70 72 74 76 78 80 82 84 86 88 90 92 94 96 98 100 102 104.2 cm-1 %T Figure 1. FTIR spectrum of the biomimetic hydroxyapatite composite before (--) and after thermal threatment (--)at 900℃ Figure 2. Thermogravimetic curves of biomimetic hydroxyapatite composite