With the advent of ‘intelligent materials’ and ‘smart materials’ chemistry faces new challenges. Supramolecular host materials provide superb possibilities to be exploited in engineering of novel materials. They are highly selective in substrate bonding, reversible in action, if required, many are easily available in macro quantities (native cyclodextrins, some synthetic calixarene-type hosts, as well as some Metal Organic Frameworks and Covalent Organic Frameworks), many of those are eco-friendly an even usable in biological systems as drug carriers, food additives etc. The concept of Smart Functional Materials and Devices (SFMaD) is intended to define materials combining two or more functions together: selectivity and conservation as the minimum requirement, then signaling sorption to remote parts of the system, possibility of chemical transformation and/or signaling induced by allosteric effects, and a variety of practical results which may be associated with the properties listed above. Third generation1 metal-organic frameworks (MOFs) are dynamic materials capable of undergoing reversible structural changes, with applications including gas or vapour separation and storage,2  controlled drug delivery,3 chemical sensors4 and proton conductivity.5 In this context, there have been several reports of flexible porous materials for which the extent of guest uptake depends on structural transformations experienced by the host framework.6,7 In the present paper a review will be presented, including processes of activation of MOFs,  necessary for sorption/desorption in a controllable way, as well as enabling remote control of the processes. The review will emphasize selected results of international cooperation in the field of the Moldovan scientific teams.