Lactate dehydrogenase is a cytolytic enzyme with essential role in energy production process of the body. LDH can be found in almost all body tissues, and its level increases in response to some injuries at the cellular level. The purpose of the research was to study in vitro the mechanisms of action of the local biologic active compounds (BAC) PSS, BioR-Ge and BioR-Zn on LDH activity in healthy individuals and in persistent bronchial asthma (PBA) of different severity. The research was performed on peripheral blood samples collected from 40 patients aged between 23 and 74 years (medium age – 47 years) diagnosed with persistent asthma. Patients were divided into the following groups: I – control, that included 10 healthy people; II – 10 patients with mild form of persistent asthma; III – 10 patients with moderate form of persistent asthma; IV – 10 patients with severe form of persistent asthma. Blood samples of all patients were treated with local cyanobacterial remedies – BioR, BioR-Ge and BioR-Zn. Changes of the LDH in healthy persons and in patients with persistent bronchial asthma with different severity, and the influence of the local BAC are presented in the table below. PSS in both doses increases significantly by 4.9 and 6.7 fold (p<0.05) the LDH activity in healthy people as compared with the control group level. Other BAC did not influence the LDH activity in control group blood samples. LDH was increased 9 times in mild and moderate forms of asthma. In the severe form the LDH value was only 2 times over the control group. Tested remedies influenced the activity of LDH only in moderate and severe forms of PBA. PSS in dose of 50 μg/ml dicreased LDH activity in the moderate form (- 38%) and increased it in the severe one (+138%) compared with the non-treated samples. BioR-Ge in both doses and BioR-Zn decreased the activity of the LDH more than 3 times in moderate PBA, while in the severe form only BioR-Ge in dose of 100 ng/ml and BioR-Zn reduced the LDH activity about 2–3 times compared with nontreated samples. Changes were statistically significant. None of the tested BAC restored the normal values of LDH activity specific for healthy persones blood samples, except BioR-Ge in dose of 100 ng/ml in severe form of PBA. In conclusion, bronchial asthma was characterized by an increased activity of LDH, especially in the mild and moderate forms of the disease. Studied BAC had a positive effect on the LDH activity. It was characterized by the tendency of normalization of the enzymeactivity, especially by BioR-Ge 100 ng/ml and BioR-Zn. The studied BAC can be used as remedies for correction of carbohydrate metabolism disorders caused by bronchial asthma.