Practical use of biologically active compounds for the modulation of the metabolic processes acquires a particular importance in modern medicine. The purpose of the research was to elucidate the peculiarities of protein metabolism in experimental hepatopathy (HP) and to evaluate the mechanisms of local biologically active compounds (BAC) influence on metabolic processes in liver. The HP was induced by the administration of ethylene glycol (EG). Protein metabolism markers: total protein level, the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), the content of molecules with medium molecular mass (MMM) and of necrotic substances (NS) were determined in the liver. HP medication was performed using local BAC – cyanobacterial remedies BioR and BioR-Ge. Changes of the protein metabolism markers in the liver of the animals with HP induced by ethylene glycol (EG), and the influence of the local CBA are presented in the table below. ALT levels increased by 72% (p<0.05) and AST by 35% (p<0.05) and a tendency of the protein content reduction compared to the values of the control group was observed in EGinduced hepatopathy. Administration of the tested BAC reduced the toxic effects of EG on hepatocytes, manifested by reduction of the total protein deficit, which levels were restored to the values recorded in intact animals, and by normalization of aminotransferases activity. The most effective proved to be the compound BioR-Ge, which managed to restore the deficit of proteins and to reduce the increased activities of ALT and AST, presumably due to their ability to reduce the toxic effects of EG on the liver. BioR treatment reduced the MMM by 20% (p<0.05) and induced a trend of SN decrease by 17% (p>0.05), which can be explained by decreased catabolic processes in the liver tissue. The advance level of the pathological process in the liver achieved in our experiment was characterized by a significant increase in aminotransferase activity in the liver tissue of the experimental animals. Treatment with the tested remedies succeeded in reducing the intensity of the toxic effects of EG on hepatocytes, as certified by the recovery of the ALT and AST activities, functional level of enzymes returning to levels recorded in the reference animals. The studied BAC can be used as remedies for correction of metabolic disorders caused by toxic liver injury.