Antimicrobial and antifungal activities of some 3d metal coordination compounds of salicylaldehyde 4-allyl-s-alkylisothiosemicarbazone and its derivatives
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GULYA, Aurelian, ZARICIUC, Elena, USATAIA, Irina, GRAUR, Vasilii О., VASYLCA, M., CERNOBAI, A., TSAPKOV, Victor I., RUDIK, V.. Antimicrobial and antifungal activities of some 3d metal coordination compounds of salicylaldehyde 4-allyl-s-alkylisothiosemicarbazone and its derivatives. In: Microbial Biotechnology, 12-13 octombrie 2016, Chișinău. Chișinău, Republica Moldova: Institutul de Microbiologie şi Biotehnologie, 2016, Ediția 3, pp. 72-73.
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Microbial Biotechnology
Ediția 3, 2016
Conferința "Microbial Biotechnology"
Chișinău, Moldova, 12-13 octombrie 2016

Antimicrobial and antifungal activities of some 3d metal coordination compounds of salicylaldehyde 4-allyl-s-alkylisothiosemicarbazone and its derivatives


Pag. 72-73

Gulya Aurelian1, Zariciuc Elena2, Usataia Irina1, Graur Vasilii О.1, Vasylca M.1, Cernobai A.1, Tsapkov Victor I.1, Rudik V.3
 
1 Moldova State University,
2 ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
3 Institute of Microbiology and Biotechnology of the ASM
 
Proiecte:
 
Disponibil în IBN: 13 martie 2019



Teza

Chrome(III), iron(III), cobalt(II), nickel(II), copper(II) and zinc(II) salts react with salicylaldehyde (HL1,5), 3-methoxysalicylaldehyde (HL2,6), 2-hydroxyacetophenone (HL3) and 2-hydroxy-1-naphthaldehyde (HL4) 4-allyl-S-methyl- and 4-allyl-S-ethylisothiosemicarbazones forming coordination compounds with composition: M(L1–4)X·nH2O (M=Cu, Zn; X=Cl- , Br-, NO3 -, ClO4 -; n=0–2), Ni(L1–4)2, M(L1–4)2X (M= Cr, Fe, Co; X=Cl-, Br-, NO3 -, ClO4 -). The study of antimicrobial and antifungal activities of synthesized substances towards Escherichia coli, Salmonella abony, Staphylococcus aureus, Enterococcus faecalis, and Candida albicans shows that these substances possess both bacteriostatic and bactericidal activities towards all studied strains in the range of concentrations 0.7–1000 μg/mL. It was determined the HL1 isothiosemicarbazone manifests a weak antimicrobial activity. Meanwhile, the introduction of a methoxy group into the third position of salicylidene moiety increases 2–33 times the activity towards the whole gamut of microorganisms. The substitution of salicylidene moiety by 2-hydroxy-1-naphthalidene fragment also leads to the growth of activity, but in this case there is a considerable difference in activity towards gram-positive and gram-negative bacteria. The activity towards gram-negative bacteria increases 2 times, but the activity towards gram-positive bacteria and Candida albicans fungus increases 1500 times. In case of HL1 coordination to the copper (II) ions the antimicrobial activity increases 4–33 times towards all studied microorganisms. In case of some microorganisms the iron coordination compounds also are slightly more active than corresponding isothiosemicarbazone. In case of nickel and chromium coordination compounds the change of activity is insignificant. In case of cobalt coordination compounds there is also a decrease of activity in some cases. In case of 2-hydroxy-1-naphthaldehyde 4-allyl- S-methylisothiosemicarbazone the coordination to the biometal ions doesn’t lead to the growth of antimicrobial activity and leads to a significant decrease of antifungal activity. The comparison of coordination compound of salicylic aldehyde S-methyl- and S-ethylisothiosemicarbazones (HL1 and HL5) shows that substitution of methyl group by ethyl group leads to a slight growth of antifungal activity and antimicrobial activity towards gram-positive bacteria. The determinated properties of the synthesized substances are of interest for medical and veterinary practice for enhancement of the arsenal of antimicrobial and antifungal preparations that are active against the resistant forms of microorganisms and fungi.