Tuberculosis evolution and treatment response are determined by the mycobacteria virulence, and the organism’s capacity to fight against the aggression of the oxidative stress through the antioxidant defense. The oxidative stress (OS) is caused by the imbalance between the systemic manifestation of the reactive oxygen species (ROS) and the ability of biological system to detoxify them and to repair the resulting damage. The disturbances in the normal redox system cause toxic effects through the peroxidation of the cellular DNA, proteins, lipids, carbohydrates and other biological macromolecules. Several biomarkers are available in the assessment of the OS. Advanced oxidation protein products (AOPP) are novel biomarkers, resulted from the interaction between the chlorine oxidants (chloramines and hypochlorous acid) with plasmatic proteins. AOPP are carried by oxidized plasma proteins, especially albumin, are excreted by the kidneys and the highest concentration were identified in patients with severe chronic renal failure, hyperparathyroidism and continuous treatment with calcium and vitamin D. Interleukin 8 (IL-8) is secreted by the macrophages, phagocytes and mesenchymal cells. It activates neutrophil chemotaxis and accumulation of the leukocytes at the site of the infection, inflammation, ischemia and traumatism. IL-8 releasing is induced by the IL-1 and TNF-α. The aim of the research was to assess the correlation between the concentration of the IL-8 and oxidative biomarkers: advanced oxidation protein products, ureea, creatinine. Material and methods: a prospective study which included 46 patients, new cases with pulmonary tuberculosis (study group-SG) were investigated according to the national protocol and compared with results of the 36 healthy persons (control group-CG). The determination of the AOPP was performed according to the modified method of Witko-Sarsat V [1]. The concentration of the IL-8, urea and serum creatinine was assessed through the spectrophotometric analysis using the kits of the producer Eliteh (France) according to the attached instructions. Results: Distribution of patients, according to the biological characteristics established a similar rate of men in both groups, with their predomination 31 (67,39±6,91%) in SG vs. 24 (66,78±7,87%) in CG, which ensured the comparability of the groups. The concentration of the AOPP in the serum was statistically higher in the SG 44,06±2,86 μMol/l compared with the CG 34,349±3,58 μMol/l (p<0,05). The concentration of the blood urea was statistically higher in the SG 18,92±9,2 mg/dL compared with the CG 13±2,28 mg/dL (p<0,05), as well of the creatinine 79,79±6,84 mg/dL vs 45,87±5,69 mg/dL (p<0,001). The concentration of the IL-8 was eleven times higher in the SG 15,595±8,411 ng/ml in the SG than in the CG 1,163±1,685 ng/ ml (p<0,001). The correlation between the serum concentration of the AOPP and IL-8 was assessed as a middle degree (r=0,29), the same degree was established for the correlation between IL-8 and ureea (r=0,32) and low degree between IL-8 and creatinine (r=0,16). Conclusion: the concentration of the proinflammator biomarker IL-8 was significantly correlated with protein oxidation products: AOPP, urea and creatinine, which demonstrated severe proteic catabolism in patients with active tuberculosis.