This communication deals with the appearance and development of the research in the field of chemistry in the Republic of Moldova; at the beginning - in chemistry sections of Moldovan Branch of the USSR Academy of Sciences and then - at the Institute of Chemistry, founded in 1959. The dynamics of changes in the structure and research subjects is traced. Data are presented concerning the research results in the field of the chemistry of coordination compounds, fine organic synthesis, natural products chemistry, physicochemical analysis, quantum chemistry, mineral resources, chemistry of natural water and purification of waste water, the preparation and utilization of active carbons, and ecological chemistry. A detailed account both of basic research and applied investigation is given. The collaboration of our scientists with their colleagues from abroad is considered. Information is presented related to the scientific schools at our institute, its guidance and laboratory′s leaders. The scientific equipment of the institute is mentioned. The relationship of the institute with higher schools, as well as training of young researchers will be presented.