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770 12 |
Ultima descărcare din IBN: 2023-05-21 00:45 |
Căutarea după subiecte similare conform CZU |
616.233-002-085-053.2 (1) |
Pathology of the respiratory system. Complaints of the respiratory organs (757) |
SM ISO690:2012 SAVOSCHIN, Dorina. Administrarea prin nebulizare a soluţiei saline hipertonice 3% la copiii cu sindrom obstructiv bronşic: studiu clinic randomizat. In: Buletin de Perinatologie, 2018, nr. 4(80), pp. 55-58. ISSN 1810-5289. |
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Buletin de Perinatologie | ||||||
Numărul 4(80) / 2018 / ISSN 1810-5289 | ||||||
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CZU: 616.233-002-085-053.2 | ||||||
Pag. 55-58 | ||||||
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Background. Several studies have suggested that the nebulization of hypertonic saline solution may be useful in treating bronchial obstruction syndrome due to its fluidization action with the decreasing of the viscosity of bronchial secretion and expectoration effect, thereby leading to clinical improvement. Aim of the study: To establish the efficacy of nebulization by administering 3% hypertonic saline solution in the treatment of patients with bronchial obstructive syndrome. Material and methods. The research was conducted at the Pulmonology and Pediatric Intensive Care Units of the Institute for Maternal and Child Healthcare, from November 2014 to March 2015. The study included 80 children with bronchial obstructive syndrome, of which 40 children received inhalation treatment with 3.5 ml of 3% hypertonic saline solution 3 times a day in association with standard treatment, whilst children in the control group were given only standard treatment, without inhalation of hypertonic saline aerosol. Children in both groups were monitored for 24 hours, during which the clinical status was assessed at the time of inclusion and at 3-hour, 12-hour, and 24-hour intervals, with the assessment of the clinical score and pulse oximetry parameters. The obtained results were processed using the EXCEL and GraphPad Software. Results. The primary outcome measured was the variation of the clinical score and respiratory symptoms. At 12 hours after the onset of the study, improvement in respiratory symptomatology was evident in both groups, however, a more evident improvement was seen in the group of children whose standard therapy was supplemented with inhalation of hypertonic saline aerosol. Thus, at the 12-hour interval from the onset of the study, 57.5% of children from the studied group manifested mild bronchial obstruction or full recovery as cmparing with 38.5% in the control group (p <0.05). Another important finding was that the duration of hospitalization was shorter for patients who benefited from the use of 3% hypertonic saline solution inhalations (7.05±0.96 vs 9.28±0.98 days in the control group, p <0.0001). Conclusions. The study results showed improvement of the bronchial obstructive syndrome in young children who received nebulized 3% hypertonic saline solution in association with standard treatment |
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Cuvinte-cheie children, bronchial obstruction, nebulization, 3% hypertonic saline solution. |
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