Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
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STUCKI, David, BRITES, Daniela, JELJELI, Leila , COSCOLLA, Mireia, LIU, Qingyun, TRAUNER, Andrej, FENNER, Lukas , RUTAIHWA, Liliana Kokusanilwa, BORRELL, Sonia, LUO, Tao, GAO, Qian, KATO-MAEDA, Midori, BALLIF, Marie, EGGER, Matthias, MACEDO, Rita, MARDASSI, Helmi, MORENO, Milagros, VILANOVA, Griselda Tudo, FYFE, Janet A.M., GLOBAN, Maria, THOMAS, Jackson, JAMIESON, Frances B, GUTHRIE, Jennifer L, ASANTE-POKU, Adwoa, YEBOAH-MANU, Dorothy, WAMPANDE, Eddie M., SSENGOOBA, Willy, JOLOBA, Moses Lutaakome, BOOM, Henry Henry, BASU, Indira, BOWER, James E., SARAIVA, Margarida, VASCONCELLOS, Sidra_Ezídio_Goncalves, SUFFYS, Philip Noel Oel, KOCH, Anastasia S., WILKINSON, Robert, GAIL-BEKKER, Linda, MALLA, Bijaya , LEY, Serej, BECK, Hans Peter, DE JONG, Bouke C., TOIT, Kadri, SANCHEZ-PADILLA, Elisabeth, BONNET, Maryline, GIL-BRUSOLA, Ana, FRANK, Matthias, PENLAP BENG, Veronique N., EISENACH, Kathleen D., AL-ANI, Issam , NDUNG'U, Perpetual Wangui, REVATHI, Gunturu, GEHRE, Florian, AKTER, Suriya, NTOUMI, Francine, STEWART-ISHERWOOD, Lynsey, NTINGINYA, Nyanda Elias, RACHOW, Andrea, HOELSCHER, Michael, CIRILLO, Daniela, SKENDERS, Girts, HOFFNER, Sven Erik, BAKONYTE, Daiva, STAKENAS, Petras, DIEL, Roland, MOLDOVAN, Olga, KRUDU, V., AL-HAJOJ, Sahal Abdulaziz M., OTERO, Larissa, BARLETTA, Francesca, CARTER, E. Jane, DIERO, Lameck O., SUPPLY, Philip, COMAS, I., NIEMANN, Stefan, GAGNEUX, Sebastien P.. Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages. In: Nature Genetics, 2016, vol. 48, pp. 1535-1543. ISSN 1061-4036. DOI: https://doi.org/10.1038/ng.3704
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Nature Genetics
Volumul 48 / 2016 / ISSN 1061-4036 /ISSNe 1546-1718

Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
DOI:https://doi.org/10.1038/ng.3704

Pag. 1535-1543

Stucki David1, Brites Daniela1, Jeljeli Leila 2, Coscolla Mireia1, Liu Qingyun3, Trauner Andrej1, Fenner Lukas 4, Rutaihwa Liliana Kokusanilwa1, Borrell Sonia5, Luo Tao6, Gao Qian3, Kato-Maeda Midori7, Ballif Marie8, Egger Matthias9, Macedo Rita10, Mardassi Helmi11, Moreno Milagros12, Vilanova Griselda Tudo13, Fyfe Janet A.M.14, Globan Maria14, Thomas Jackson4, Jamieson Frances B15, Guthrie Jennifer L16, Asante-Poku Adwoa17, Yeboah-Manu Dorothy17, Wampande Eddie M.18, Ssengooba Willy19, Joloba Moses Lutaakome19, Boom Henry Henry20, Basu Indira21, Bower James E.21, Saraiva Margarida22, Vasconcellos Sidra_Ezídio_Goncalves23, Suffys Philip Noel Oel23, Koch Anastasia S.24, Wilkinson Robert25, Gail-Bekker Linda24, Malla Bijaya 1, Ley Serej1, Beck Hans Peter1, De Jong Bouke C.26, Toit Kadri27, Sanchez-Padilla Elisabeth28, Bonnet Maryline28, Gil-Brusola Ana29, Frank Matthias30, Penlap Beng Veronique N.31, Eisenach Kathleen D.32, Al-Ani Issam 33, Ndung'U Perpetual Wangui34, Revathi Gunturu35, Gehre Florian36, Akter Suriya26, Ntoumi Francine37, Stewart-Isherwood Lynsey38, Ntinginya Nyanda Elias39, Rachow Andrea40, Hoelscher Michael41, Cirillo Daniela42, Skenders Girts43, Hoffner Sven Erik44, Bakonyte Daiva45, Stakenas Petras45, Diel Roland46, Moldovan Olga47, Krudu V.48, Al-Hajoj Sahal Abdulaziz M.49, Otero Larissa49, Barletta Francesca50, Carter E. Jane51, Diero Lameck O.52, Supply Philip53, Comas I.54, Niemann Stefan2, Gagneux Sebastien P.27
 
1 Institutul Tropical şi de Sănătate Publică,
2 Research Center Borstel,
3 Fudan University, Shanghai,
4 Ifakara Health Institute, Ifakara,
5 University of Basel,
6 Sichuan University,
7 University of California, San Francisco,
8 Institut fur Sozial- und Praventivmedizin, Basel,
9 University of Bern,
10 Santa Maria Hospital, Lisbon,
11 University of Tunis El Manar, Tunis,
12 Hospital Nossa Senhora da Paz,
13 Instituto de Salud Global de Barcelona, Barcelona,
14 Victorian Infectious Diseases Reference Laboratory,
15 University of Toronto,
16 Ontario Public Service, Toronto,
17 University of Ghana, Legon,
18 Makerere University, College of Health Sciences, Kampala,
19 University of Amsterdam,
20 Case Western Reserve University, Tuberculosis Research Unit, Cleveland,
21 LabPLUS, Auckland,
22 Universidade do Minho, Escola de Ciencias da Saude, Braga,
23 Fundacao Oswaldo Cruz, Laboratório de Biologia Molecular Aplicada a Micobactérias, Rio de Janeiro,
24 University of Cape Town, Cape Town,
25 Imperial College London,
26 Prins Leopold Instituut voor Tropische Geneeskunde, Antwerpen,
27 Tartu University Hospital,
28 Epicentre, Department of Clinical Research, Paris,
29 Hospital Clinico Universitario de Valencia,
30 Universitat Tubingen, Institute of Tropical Medicine, Tubingen,
31 University of Yaoundé I,
32 Universitatea Arkansas for Medical Sciences,
33 Faculty of Medical Technology, Department of Medical Laboratory Technology, Baghdad,
34 Jomo Kenyatta University of Agriculture and Technology, Institute of Tropical Medicine and Infectious Diseases, Nairobi,
35 Aga Khan Hospital Nairobi, Department of Pathology, Nairobi,
36 Medical Research Council Unit, Vaccines and Immunity Theme,
37 Fondation Congolaise pour la Recherche Médicale,
38 University of Witwatersrand,
39 Mbeya Medical Research Programme,
40 Centre for Respiratory Disease Research at KEMRI,
41 Ludwig-Maximilians University,
42 IRCCS San Raffaele Scientific Institute, Milan,
43 Riga East University Hospital,
44 Public Health Agency of Sweden,
45 Vilnius University,
46 Universitatsklinikum Schleswig-Holstein Campus Kiel, Institute for Epidemiology,
47 Institutul de Pneumologie „Marius Nasta“,
48 Institute of Phtysiopneumology „Chiril Draganiuc”,
49 Peruvian University Cayetano Heredia, Lima,
50 Brown University,
51 Academic Model Providing Access to Healthcare,
52 University of Lille,
53 Universitat de València,
54 Swiss Tropical and Public Health Institute (Swiss TPH)
 
 
Disponibil în IBN: 6 noiembrie 2017
Rezumat

Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.
Cuvinte-cheie
MeSH DNA, Bacterial, Genomics, genotype, Global Health, Humans, Mycobacterium tuberculosis, Phylogeography, polymorphism, genetic, Tuberculosis EMTREE drug terms bacterial DNA EMTREE medical terms allele, article, bacterium isolate, controlled study, genetic variability, geographic distribution, host pathogen interaction, host range, human, Mycobacterium tuberculosis, nonhuman, phylogenetic tree, priority journal, Sanger sequencing, Single nucleotide polymorphism, T lymphocyte, whole genome sequencing, classification, genetic polymorphism, genetics, Genomics, genotype, Global Health, isolation and purification, microbiology, Mycobacterium tuberculosis, Phylogeography, procedures, tuberculosis

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