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SM ISO690:2012 GROSU, Aurel, DAVID, Lilia, CUZOR, Tatiana, RIZOV, Mihail. Infarctul miocardic acut: posibilităţile asocierii Mildronatului la tratamentul de bază. In: Curierul Medical, 2012, nr. 1(325), pp. 6-9. ISSN 1875-0666. |
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Curierul Medical | |||||||
Numărul 1(325) / 2012 / ISSN 1875-0666 | |||||||
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Pag. 6-9 | |||||||
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The effects of Mildronate used along with basic acute myocardial infarction (AMI) therapy on the clinical, electrocardiographic and echocardiographic parameters of AMI patients (pts) were studied. Material and methods. The study enrolled 60 pts with AMI: 35 pts in the study group I, and 25 in the control group II. Besides the basic AMI treatment according to the respective National Protocol, group I subjects received Mildronate 1.0 gr/day by i/v perfusion for the first 7 days, then orally in tablets for the next 6 weeks. Blood pressure, cardiac rhythm, clinical and ECG signs of myocardial ischemia, manifestations of heart failure, ECG and EchoCG changes, and patients’ exercise capacity were evaluated. Results. Pts in group I less frequently developed ventricular tachyarrhythmia, ventricular extrasistolia, atrial fibrillation, recurrent myocardial ischemia and showed in a smaller proportion in hospital progression for heart failure. Faster changes of the ST segment towards the isoelectric line, a positive evolution of the left ventricle size, improvement of the regional wall kinetics and a better exercise capacity by a 6 minute walk test were determined in pts treated with Mildronate. No adverse reactions during the treatment with Mildronate were observed. Conclusions. Use of Mildronate along with basic acute myocardial infarction treatment showed a positive effect on the echocardiografic post-infarct changes of the left ventricle and a favorable influence on the patient’s clinical situation and their exercise capacity |
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Cuvinte-cheie miocardial infarction, metabolic therapy, Mildronat. |
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