Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
1048 19 |
Ultima descărcare din IBN: 2024-02-25 21:44 |
Căutarea după subiecte similare conform CZU |
546:615.31 (1) |
Inorganic chemistry (450) |
Medicaments according to their origin (478) |
SM ISO690:2012 GRAUR, Vasilii О., SAVCIN, Serghei, TSAPKOV, Victor I., GULYA, Aurelian. Synthesis and antitumor activity of copper, nickel and cobalt coordination compounds with 1-(2-hydroxyphenyl)ethanone N(4)-allyl-3-thiosemicarbazone. In: Studia Universitatis Moldaviae (Seria Ştiinţe Reale şi ale Naturii), 2015, nr. 1(81), pp. 210-215. ISSN 1814-3237. |
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Studia Universitatis Moldaviae (Seria Ştiinţe Reale şi ale Naturii) | ||||||
Numărul 1(81) / 2015 / ISSN 1814-3237 /ISSNe 1857-498X | ||||||
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CZU: 546:615.31 | ||||||
Pag. 210-215 | ||||||
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The paper presents the synthesis of the ligand 1-(2-hydroxyphenyl)ethanone N(4)-allyl-3-thiosemicarbazone (H2L)
and six coordination compounds of copper, nickel and cobalt with this ligand. The structure of thiosemicarbazone H2L was studied using 1H and 13С NMR spectroscopy. The synthesized coordination compounds were studied using elemental analysis, gravimetric analysis of water content, molar conductivity, and magnetochemistry. For H2L the antitumor activity towards human leukemia HL-60 cells and cervical cancer HeLa cells was determined. It was established that the substitution of hydrogen atom with methyl group in the azomethinic fragment leads to the growth of antitumor activity. |
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