Background: Some migraine patients complain of ocular pain during migraine crisis. Eye pain can be unilateral or bilateral, independent of the location of headache and is distinguished by the character and intensity of pain. Sensory innervation of the eye and periocular region is provided by the I branch of the trigeminal nerve. Recurrent branches of V nerve innervate the dura mater encefali, intracranial venous sinuses and cerebral vessels. This explains why in extraophthalmic pathologies, headache may radiate into the eye and orbit, and in ocular disease may radiate in different areas of the head and face. Retrobulbar pain may be associated with some types of primary headache, optic nerve pathology, pathology of the eyeball itself or tumor, endocrine or vascular damages of orbit. There is a wide range of neurological diseases with secondary pain to orbital region , periorbital and retrobulbar region, conditional pain related to organic brain pathology. Eyes pain may be a sign of suffering from orbital apex, inflammatory origin in optic neuritis, myositis or Graves-Basedow disease. Sometimes retrobulbar pain is a sign of the presence of an intracerebral aneurysm or fistula carotidcavernous onset, while short pain, is a sign of a neuralgic pain. Ophthalmologist has the first obligation to detail the circumstances of the occurrence of pain, or its association with other symptoms, of which the most common are decreased visual acuity, ocular congestion and/or presence tearing or conjunctival secretions. Conclusion: To differentiate migraine eye pain origin and organic origin it is necessary to know some features of their manifestation .