On the basis of theoretical material analysis, it was observed that the music evolved simultaneously with her instruments for interpretation. The present musical instruments have contributed to the formation of actual music, and therefore, of contemporary composers. Also, was mentioned the interrelationship between the technical and scientific discoveries of the 19th and 20th centuries and the construction of new musical instruments. The incursion in the history of using of the synthesizer allowed us to establish the most important solutions afforded by this instrument in the creation of new musical works. A brief description of the activity of composers M. Afanasiev, V. Burlea, Gh. Ciobanu, V. Dânga, E. Fiștic was conducted to determine the impact of new technologies on the development of Moldovan musical art.