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SM ISO690:2012 CONDREA, Eugeniu. Cefaleea ca manifestare clinică a adenoamelor hipofizare. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2010, nr. 4(11), pp. 146-152. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | ||||||
Numărul 4(11) / 2010 / ISSN 1857-1719 | ||||||
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Pag. 146-152 | ||||||
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Headache in clinical manifestation of pituitary tumors
The objective of the study is to analyze the presence of headache in pituitary tumors and
their characteristics, the relationship between tumor size, biological type, local extension and intrasellar pressure (ISP). This is a prospective study, of 64 consecutive patients presenting with primary pituitary masses at Neurosurgical department of Institute of Neurology and Neurosurgery of Chisinau, Republic of Moldova from January 2005 to December 2009. We analyzed all basic characteristic of headache and divided them into groups by age, sex, type of headache (laterality, site, severity, quality, frequency, duration, associated symptoms, , time of onset, trigger, alleviating factors and familial history) and tumor characteristics (type, size, quiasmatic compression, cavernous sinus invasion, sella turcica distruction, cystic or solid mass and intrasellar pressure). We observed a statistic significant correlation between headache and tumor size, optic chiasm compression, sellar destruction, cavernous sinus invasion and ISP. Biochemical- neuroendocrine factors, mainly in prolactinomas, seem to be an important factor in the determination of headache. The presence of headache in pituitary tumors is related to a combination of factors, including ICP, tumor extension, relationship within the sellar structures, patient predisposition, familial history, and functional disturbances. |
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