The classical form of Gruss’ inequality, first published by G.Gruss in 1935, gives an estimate of the difference between the integral of the product and the product of the integrals of two functions. In the subsequent years, many variants of this inequality appeared in the literature. The aim of this paper is to introduce a new approach, presenting a new Chebyshev-Gruss-type inequality and applying to different well-known linear, not necessarily positive, operators. Some conjectures are presented. We also compare the new inequalities with some older results. In some cases this new approach gives better estimates than the ones already known.