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SM ISO690:2012 MARGA, Simion. Cancerul colorectal – viziuni actuale asupra evoluţiei clinice. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2010, nr. 3(11), pp. 741-747. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | ||||||
Numărul 3(11) / 2010 / ISSN 1857-1719 | ||||||
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Colorectal cancer – the present vision about clinical evolution
Colorectal cancer (CRC) is one of the most common cancer types in the world, being the
cause of 10% deaths among the patients deceased because of cancer. This study assesses the etiology of CRC including genetic and environmental factors, characteristic features, clinical discoveries and evolution of this disease by analyzing international publications in the
application domain. Risk factors for CRC include: age, diet, reduced physical activity, intestinal inflammatory diseases, and genetic factors. Though, the environmental factors catalyze the development of CRC in those who are genetically predisposed, there is a number of hereditary factors that increase disease probability. Development from a modified cell to a tumor with metastases takes place gradually, progressing from the normal mucosa to adenoma and finally to invasive carcinoma. Classical symptoms of CRC are rarely seen today in contemporary colorectal practice. Taking in consideration progresses in diagnostic technologies, there may be done a lot at the level of clinical examination. In conditions of out-patients department, general medical examination of the patient and rectal examination by finger, followed by sygmoidoscopy and proctoscopy, provide accurate clinical evaluation. Creation of multidisciplinary teams for case discussion and treatment coordination is a fundamental element in CRC therapy. Because of high incidence of CRC, and a relatively long period of time for adenoma to develop into malignant tumor, the screening modalities were studied for the purpose of early detection and achievement of better results in CRC treatment. Despite the fact that genetic process that stands at the base of development of disease was identified, practically it did not influence CRC prevention or improve the methods of treatment. The progress in amelioration of this situation might be obliged to introducing of screening. |
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