The article includes an analysis of the data on the primary cycle vaccination coverage (VC) of children aged 15-26 months (N 1341) with the vaccines in the framework of the National Immunization Program (NIP) from 34 localities of Moldova in accordance with the criteria recommended by the WHO. The values of the general VC and ones referring to the age of 12 months (MMR – 15 months) have been calculated as well as the proportion of children who have not completed the immunization program. The level of the general VC has been uneven, and it is the lowest in the city of Chisinau (MMR – 86.1 ± 3.0%, DPT – 90.0 ± 2.6%) compared with the other urban and rural areas. Nationwide, this figure for the most vaccines is at the level envisaged by NIP (≥ 95%), with the exception of the MMR and Hib vaccines, whose figures are 89.3 ± 1.7% and 68.7 ± 2.5% respectively. The analysis of the VC up to target age of 12 months shows that on many issues its level set by the NIP has not been reached, and there is a significant number of susceptible children that may contribute to the spread of infectious diseases when a source of infection emerges. A complex of organizational and methodical measures is needed for immunization strictly according to the national immunization schedule.