<?xml version='1.0' encoding='utf-8'?>
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<creators>
<creator>
<creatorName>Popuşoi, A.</creatorName>
<affiliation>Universitatea de Stat din Moldova, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Barbă, N.</creatorName>
<affiliation>Universitatea de Stat din Moldova, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Gulea, A.P.</creatorName>
<affiliation>Universitatea de Stat din Moldova, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Roy, J.</creatorName>
<affiliation>Université Laval, Québec, Canada</affiliation>
</creator>
<creator>
<creatorName>Poirier, D.</creatorName>
<affiliation>Université Laval, Québec, Canada</affiliation>
</creator>
<creator>
<creatorName>Prisacari, V.I.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
</creators>
<titles>
<title xml:lang='en'>Synthesis and biologic properties of some1-(alchyl) phenyl-3-(4-(3-(pyridin-2 il)
acryloyl)phenylthiourea
</title>
</titles>
<publisher>Instrumentul Bibliometric National</publisher>
<publicationYear>2013</publicationYear>
<relatedIdentifier relatedIdentifierType='ISSN' relationType='IsPartOf'>1857-1727</relatedIdentifier>
<subjects>
<subject>chalcones</subject>
<subject>isothiocyanatopropenones</subject>
<subject>thioureas</subject>
<subject>antibacterial activity</subject>
<subject>Antifungal activity</subject>
<subject>antiproliferative
activity</subject>
</subjects>
<dates>
<date dateType='Issued'>2013-02-01</date>
</dates>
<resourceType resourceTypeGeneral='Text'>Journal article</resourceType>
<descriptions>
<description xml:lang='en' descriptionType='Abstract'>This paper describe the synthesis of some 1-(alchyl)aril-3-(4-(3-pyridin-2-il) acryloyl)phenylthiourea obtained by condensation of 2-pyridincarboxaldehide with some derivatives of 4-acetylphenilthioureas in basic medium or by addition of aliphatic and aromatic amines to the correspondingisothiocyanatopropenones. 12 new compounds
were obtained and their biological properties were analysed. The substituted thioureas by pyridine radicals, morpholine
and phenol show a maximum bacteriostatic activity for Gram positive microorganisms like: Staphylococcus Aureus and Enterococcus Faecalis at the minimum inhibitory concentration 9.37-37.5 μM. Antifungal activity for Candida Albicans, Aspergillus Niger, AspergillusFumigatus, Penicillium is weak, in minimum inhibitory concentration 600->600 μM. The leukemia activity like inhibitor (HL-60), is 84-96.9% at the concentration 10-5mol/l and 15-20% and at the concentrations 10-6, 10-7mol/l.</description>
</descriptions>
<formats>
<format>application/pdf</format>
</formats>
</resource>