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SM ISO690:2012 DOLMA, Nadejda, BEŢIU, Mircea. The epidemiological, clinical and immunological, and genetic aspects of atopic dermatitis. In: Curierul Medical, 2013, nr. 3(56), pp. 64-71. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 3(56) / 2013 / ISSN 1875-0666 | ||||||
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Pag. 64-71 | ||||||
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Taking into consideration the expanding morbidity, chronic course of the disease with frequent relapses as well as ineffective treatment and prophylactic measures, atopic dermatitis (AD) represents one of the most important issues for healthcare system specialists. AD is a multi-factorial and poly-gene disease conditioned by genetically encoded specific immune and non-immune patterns. In this article the updated data on epidemiology, pathogenesis and clinical characteristics of AD are presented. The role of cytokines in the pathogenesis of various forms and stages of AD is presented as well as the new data concerning allele polymorphism of cytokine genes. The identified clinical and evolutive, immuno-genetic, HLA-system features of the disease allow the determining of the phenotype of atopic dermatitis. The differentiated approach to the evaluation of the parameters for such forms of AD as “extrinsic” and “intrinsic” can be used as screening in the pediatric and family medicine for identifying risk factors and predicting the disease prognosis. |
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Cuvinte-cheie atopic dermatitis, morbidity, cytokines, HLA, “extrinsic” |
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