Characteristics differentiation syndrome in treatment of patients with acute promyelocytic leukemia It was examined clinical features, incidence and prognostic factors of differentiation syndrome (DS) in induction therapy in 83 patients with acute promyelocytic leukemia with age from 5 to 71 years ( female-55, male-28). Severe DS was registered in 9 (10,8%) patients, moderate DS - 23 (27,7%) cases. In most causes (71,9%) there were registered late DS. WBC count greater than 5,0x109/l was appeared as unfavorable factor of developing DS. Key words: . differentiation syndrome, acute promyelocytic leukemia.

A fost studiată caracteristica clinică, frecvenţa şi factorii prognostici a sindromului de diferenţiere ( SD) în perioada de inducere a remisiunii la 83 pacienţi cu leucemie acută promielocitară în vîrsta de la 5 pînă la 71 ani ( femei-55, bărbaţi-28). La 32 ( 38,5%) patienţi s-a dezvoltat SD. Forma gravă a SD a fost înregistrată la 9 (10,8%) bolnavi, forma de gravitate medie –în 23 ( 27,7%) cazuri. În majoritatea cazurilor (71,9%) s-a inregistrat SD tardiv. Numărul de leucocite mai mare de 5,0x 10 9/l constituie un factor prognostic nefavorabil pentru dezvoltarea SD.