Introduction. According to WHO data, depression is becoming more and more serious condition and greatly affects human physical and mental health [1]. Given the high prevalence of depression worldwide and the well-established consequences of untreated depression, the ability of physicians and pharmacists to diagnose and treat it effectively is of major importance [2]. The purpose of this work. To study the pharmacist's role in the management of depressive disorders. Material and methods. The investigation of 77 bibliographic sources from the PubMed database and from specialized journals was carried out regarding risk factors, consequences and the pharmacist's role in the management of depression. Results. Following the analysis of clinical studies, it was found that depressive states are manifested by the following symptoms: sadness (21%), anxiety (19%), pessimism (16%), fatigue (14%), insomnia (9%), anorexia or bulimia (7%), restlessness (6%), headache (5%), digestive disorders (3%). It was found that the most used antidepressant preparations in medical practice among tricyclic antidepressants are amitriptyline (56%); among selective serotonin reuptake inhibitors: fluoxetine (33%), sertraline (52%) and escitalopram (15%), and among serotonin and norepinephrine reuptake inhibitors - venlafaxine (28%). Comorbid depression and anxiety disorders occur in up to 25% of general medical school students. 23 clinical studies were analyzed and it was determined that the presence of clinical pharmacists in the healthcare team of patients with depression has a positive impact in increasing the effectiveness of the performed treatment and in preventing relapses. The pharmacist's role is to recommend lifestyle changes, practicing sports, a diet rich in vitamins and vitally important nutrients, and ensuring an optimal quality and quantity of sleep. Patients are encouraged to appeal to family and friends, to volunteer or be enrolled in courses that they enjoy, social support contributing to improvement of reintegration of depressed people into society. Conclusions. Clinical pharmacist interventions significantly improved the quality of pharmacotherapy by reducing the total number of medications and led to better adherence to treatment guidelines for various pathologies, including depression.