The article examines the potential role of international actors in solving Transnistrian conflict, as well as the conflict itself, which represents the main unresolved problem of the Republic of Moldova, and undoubtedly one of the constituent parts of destabilization and insecurity in the South-Eastern Europe. Authors bring some possible considerations with regard to achievements of international community in settlement process and problems met by both the Republic of Moldova and “important actors” in this region: Russia, Ukraine, OSCE, EU and USA. Looking briefly on the roots of this problem, one can find some traces of “big players” in the region. During all this years Russia became a dominant instigator and mediator and peacemaker in Moldova, unfortunately in vast majority western powers involvement in the process was sporadic and unnoticeable. It is mentioned that, thanks to the Ukrainian neighbor the situation has changed once the new customs regulations were introduced. Ukraine and Moldova are now sharing the common border with the EU and such measures ensure security in the region. Mainly the role of OSCE in some private negotiations is determined as a Russian tool on troop’s withdrawal. But even OSCE often was cut off the process by the Transnistria, by blocking their access to the Security zone. The paper also underline, that, the immense actors - EU and USA - could be characterized together, as immediate observers of the negotiations. During this time, Moldova directed all efforts to the adjustment of policies and promoting the decisions in order to reach the European Integration. At the same time, this article explores mediation theory and conflict resolution. Since the 1960s, there has been a great deal of political science and psychological research on international negotiation and mediation. Much of this research has focused on the strategies and roles of mediators while paying little attention to the issue of time. While there are various third and forth party mediations to the Transnistrian conflict, many of them are not regarded by one side or the other as objective, neutral mediators. Also authors are arguing about the format of peacekeeping operation in the eastern regions of the Republic of Moldova and proposing some home-grown constructive measures, as well as way ahead ideas, like internationalization and Europeanization of the problem in the context of definitive settlement of the Transnistrean conflict.