Waste management is one of the important problems thatthe Republic of Moldova is facing in environmental protection activities. At present, the problem of waste is manifesting more acutely, due to the increase of its quantity and diversity, as well as of its more pronounced negative impacton the environment. The urban and industrial development of the localities, as well as the general increase of the living standard of the population, entails the production of huge quantities of waste. In order to implement a sustainable Municipal Solid Waste Management System, it is necessary, first of all, to create premises for the separate collection of waste. This article analyses the theoretical and practical aspects of organizing the separate collection of waste in rural and urban areas. At the same time, the authors aim to cross the path of waste circularity from collection to recycling, but also to identify good practices regarding the organization of the integrated waste management system.The research was conducted within the State Program 20.80009.0807.22 Developing the circular economy mechanism for the Republic of Moldova.