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SM ISO690:2012 BUJOR, Dina, REVENCO, Ninel, HORODIŞTEANU-BANUH, Adela, CÎRSTEA (BUGA), Olga, BALANUȚA, Ana-Mihaela, SAVOSCHIN, Dorina. Antimicrobial resistance of streptococcus pneumoniae in the vaccination era. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 386. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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Pag. 386-386 | ||||||
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Background. Several studies have shown that the implementation of the conjugate pneumococcal vaccine results in a decrease in the rate of nasopharyngeal carriage of antibioticresistant pneumococcus and its replacement with non-vaccine serotypes. Objective of the study. To elucidate the prevalence and antimicrobial susceptibility of nasopharyngeal isolates of Streptococcus pneumoniae in children under 5 years of age with acute respiratory infection. Material and Methods. A cross-sectional, prospective descriptive study was conducted. The study included children with acute respiratory infections. Nasopharyngeal secretions were taken by the nasopharyngeal aspirate technique. Antimicrobial susceptibility has been interpreted according with EUCAST standards. Statistical data analysis was performed in the Microsoft Office Excel 2016 program. Results. The total group included 105 children under 5 years of age (mean 18±1.27 months), with a boy / girl ratio = 0.98 / 1. The pneumococcal vaccine was given in 91% of cases. Microbiological examination identified Streptococcus pneumoniae in 5.71% of the samples. Pneumococcal isolates showed antimicrobial resistance to: trimethoprim / sulfamethoxazole - 100%, benzylpenicillin, amoxiclav, amoxicillin, piperacillin, clarithromycin, azithromycin and vancomycin – 33.3%, and to cefaclor and erythromycin - 50%. They were sensitive to clyndamycin, linezolid, tetracycline and chloramphenicol - 100%, vancomycin and rifampicin 66.6% and to moxifloxacin, erythromycin, clarithromycin 50%. Conclusion. Although the antimicrobial susceptibility of Streptococcus pneumoniae appears to be of concern, its relatively low prevalence (5.71%) among the cases analyzed suggests a positive impact of the implementation of antipneumococcal vaccine immunization programs. |
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Cuvinte-cheie Conjugated pneumococcal vaccine, antimicrobial resistance, streptococcus pneumonia, vaccin pneumococic conjugat, rezistenţă antimicrobiană, streptococcus pneumonia |
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