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616.98:578.834:[575.113+579.61] (1) |
Communicable diseases. Infectious and contagious diseases, fevers (585) |
Virology (442) |
General genetics. General cytogenetics (427) |
Applied microbiology (368) |
SM ISO690:2012 COLAC, Svetlana, BURDUNIUC (POPA), Olga, APOSTOL, Mariana. Who-wide sequencing of COVID-19 infection and phylogenetic analysis of SARS-CoV-2 isolates. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 136. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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CZU: 616.98:578.834:[575.113+579.61] | ||||||
Pag. 136-136 | ||||||
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Background. Coronavirus genome-wide sequencing and publication of data obtained are essential for evaluating the performance of PCR test systems used, tracking the spread of the virus, determining its genetic variability, and developing the vaccine. Objective of the study. Identification of mutation variants of SARS-CoV-2 virus with phylogenetic analysis of circulating isolates on the territory of the Republic of Moldova. Material and Methods. The identification of genetic variants and the determination of the type of mutations was performed by the method of sequencing the fragments using the Ion Torrent Genexus tool and using the Pangolin and GISAID programs. Results. In the Republic of Moldova, the first sequencing of the SARS-CoV-2 virus was performed at the end of 2021 – 47 biological samples were investigated. According to the results of the investigations, the Delta variant was identified in all 47 samples. Moreover, during 2022, 144 biological samples were sequenced, selected according to all clinical, epidemiological and laboratory diagnostic criteria. Following the sequencing, the following results were obtained: in 141 biological samples the Omicron variant was identified, of them 57 presented the BA.2 line and 84 samples the BA.1 line, and in 3 samples the Delta variant was identified. Conclusion. Following the study, it was found that the Delta version circulated on the territory of the Republic of Moldova in the second half of 2021. At the beginning of 2022, the Omicron version begins to appear. At the beginning of the Omicron variant, line BA.1 predominated. |
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Cuvinte-cheie COVID-19, sequencing, genome, COVID-19, secvențierea, genom |
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