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Articolul precedent |
Articolul urmator |
226 4 |
Ultima descărcare din IBN: 2024-02-17 16:14 |
Căutarea după subiecte similare conform CZU |
616.94-036.1-07-036.1-08-091 (1) |
Communicable diseases. Infectious and contagious diseases, fevers (585) |
SM ISO690:2012 BUNESCU, Irina, TÂRCĂ, Tiberiu, BURDUNIUC (POPA), Olga, ANTON (BIVOL), Maria, SYNYTSINA, Yuliia. Clinical-evolutionary and diagnostic particularities in septicemia. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 130. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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CZU: 616.94-036.1-07-036.1-08-091 | ||||||
Pag. 130-130 | ||||||
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Introduction. In Europe, about 500 thousand cases of sepsis are registered annually, the lethality being 30-90%, and the bacteria involved are multidrug-resistant requiring expensive treatment. The purpose of the paper. Determination of clinical-evolutionary features and etiology of sepsis in patients with positive blood cultures and / or CSF. Material and Methods. To identify beta-lactamase or carbapenemaseproducing bacteria, phenotypic tests (double disc synergy, combined discs (MastDisk Combi), Amp-C cloxacillin test, Normand Poirel test, MAST CARBA PacE) and molecular diagnosis were performed. The KPC, OXA-48, MBL resistance genes were tested by 2 methods: Combo Test, Carbi Plus Combi, and the OXA-48 gene was further tested by immunocormatographic tests. Genotypic methods (PCR) identified carbapenemase-producing bacteria and resistance genes NDM, VIM, IMP. Results. During the years 20192021, in the patients hospitalized in SCR „T. Mosneaga ”, out of 59 from blood cultures and a positive CSF, bacteria were isolated: K.pneumoniae - 83.0%, E.coli - 16.94%. The presence of ESBL enzymes was determined in 40.67% of cases, of carbapenemases in 33.89% of cases, and in 8.4% of cases, the bacteria produced carbapenemases + ESBL. 94.91% of patients were hospitalized in the intensive care unit, 5.09% - surgery, urology and internal medicine. Men were affected in 71.18% of cases, and women in 28.81% of cases. Conclusions. Microbial resistance is a serious social and economic burden for the Republic of Moldova as well. 94.9% of patients with infections caused by multidrug-resistant bacteria are hospitalized in the intensive care unit. K. pneumoniae and E. coli are the most common enterobacteria in the etiology of sepsis. |
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Cuvinte-cheie sepsis, ESBL, carbapenemases, multi-resistant bacteria, sepsis, septicemii, beta-lactamaze, carbapenemaze, bacterii multi-rezistente |
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