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Ultima descărcare din IBN: 2023-11-22 11:32 |
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577.27:612.017:616-097 (1) |
Material bases of life. Biochemistry. Molecular biology. Biophysics (664) |
Physiology. Human and comparative physiology (725) |
Pathology. Clinical medicine (6963) |
SM ISO690:2012 CRUDU, Jana. The role of oxidative stress in the triggering of autoimmune diseases. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 46. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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CZU: 577.27:612.017:616-097 | ||||||
Pag. 46-46 | ||||||
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Background. Autoimmune diseases include a heterogeneous group of disorders associated with loss of immunological tolerance to autoantigens. These are the result of complex reaction, with the involvement of triggers that induce a certain degree of oxidative stress, which directly affects the immune cells. Objective of the study. Analysis and understanding of the role of oxidative stress in triggering a number of autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, etc. Material and Methods. The literature review was developed based on the analysis of contemporary specialized scientific information. Results. Oxidative stress is an effect of the redox imbalance between reactive oxygen species (ROS) and antioxidant defense, with oxidizing species primarily including free radicals (FR). The two main families of oxidants relevant in biology are reactive oxygen species (ROS) and reactive nitrogen species (RNS). Under physiological conditions, the defenses counterbalance the production of ROS and RNS, but in conditions of excessive production or if the body’s defenses are compromised, ROS and RNS can react with fatty acids, causing proteins and DNA to damage these substrates. Conclusion. This review demonstrates the close relationship between oxidative stress and the onset of autoimmune diseases. ROS overproduction will cause oxidation of proteins, lipids, change of DNA bases and breakage of the chain or even lead to cell damage. |
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Cuvinte-cheie oxidative stress, autoimmune diseases, free radicals, autoantibodies, stres oxidativ, boli autoimune, radicali liberi, auto-anticorpi |
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