Malaria, one of the deadliest infectious diseases, has been reported to infect the Italian people since the first century (1). Although malaria was eradicated from Europe in the mid-twentieth century (1), a few cases have been reported in different regions (2, 3). In 2015, the World Health Organization (WHO) European Region reported no cases of indigenous malaria for the first time (4). The disease remained endemic in tropical regions, including sub-Saharan Africa, South East Asia, and South America (5). In 2020, the number of malaria cases was estimated at 241 million, claiming 627,000 lives (5). In the same year, Africa accounted for 96% of malaria cases and 98% of malaria-associated deaths (6). According to the WHO, countries that have had no indigenous cases for at least 3 consecutive years are considered to have eliminated malaria (5). In 2021, China and El Salvador were certified malaria-free after 4 years without malaria cases (5). Malaysia, the Islamic Republic of Iran, Belize, and Cabo Verde are on the path to malaria elimination (5). According to the WHO, Europe is free of indigenous malaria cases (5). Malaria cases are principally imported by international travelers and immigrants (7). Data from the European Network on Surveillance of Imported Infectious Diseases revealed that “European travelers” represented 52.4% of patients with malaria in Europe between 1999 and 2000 (8). Although sustained transmission of malaria in Europe has not been identified heretofore, cases of autochthonous transmission ofmalaria have been reported in the past (2, 3).