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SM ISO690:2012 TOFAN, Elena, BUTOROV, Ivan, GONCIAR, Veaceslav, BUTOROV, Serghei, NECULA, Gheorghe, SCUTAR, Corina. Metodă contemporană de tratament al insuficienţei cardiace cronice cu fracţie de ejecţie diminuată. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2011, nr. 3(12), pp. 74-78. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | ||||||
Numărul 3(12) / 2011 / ISSN 1857-1719 | ||||||
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Pag. 74-78 | ||||||
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Dinamics of the ecocardiographic and hemodynamic parameters under
the influence of lisinopril, losartan and their association
The aim of the study was to appreciate the effects of the ACE inhibitor lisinopril, AT-I
receptors inhibitor losartan and their combination on the dynamics of the main
ecocardiographical, hemodynamical and neurohormonal parameters in 65 patients with chronic
heart failure with the ejection fraction of the left ventricle less then 45%. In all three groups, the
administrated therapy determined a partial resolution of the dispnoea, peripheral edemas and
increase of the tolerance to physical work, but the combined therapy hurried these effects by 3-4
days sooner then in monotherapy. At the end of the treatment period, the functional class of the
CHF decreased in patients taking lisinopril by 25,8%; losartan – by 28,1% and their association –
by 36,4%, while the ejection fraction of the left ventricle increased by 26,8%, 17,2% and 40,1%,
respectively. |
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