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SM ISO690:2012 BRANIŞTE, Teodor, BRANIŞTE, Andrei. Anexinele, calciul şi proteinele fosfolipid-aglutinante în cardiomiopatia dilatativă. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2011, nr. 3(12), pp. 53-59. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | |||||
Numărul 3(12) / 2011 / ISSN 1857-1719 | |||||
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Pag. 53-59 | |||||
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Annexins, calcium and phospholipid-agglutinan tproteins in dilated cardiomyopathy
In this study, the expression and distribution of annexins V and VI in healthy
human hearts and in DCM with irreducible heart failure using Western blots were analyzed.
There was a predominant localization of annexins V and VI in cardiomyocytes in the
sarcolemma, the T tubules and intercalary disks of healthy hearts, whereas in hearts with heart
failure the two types of annexins are found in large quantities in the interstice.
Moreover, annexin V is almost absent in the cardiomyocytes. We have shown that heart with
heart failure is accompanied by over expression and translocation of annexins V and VI, from
the cardiomyocytes to the interstitial tissue. Data suggest that annexins can help to the
ventricular remodelling. |
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Cuvinte-cheie anexine, cardiomiopatie dilatativă (CMD), insuficienţă cardiacă., cardiomiocit |
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