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SM ISO690:2012 CHUMAKOV, Yurii, GRAUR, Vasilii О., ULCHINA, Ianina, SMAGLII, Vadim, GULYA, Aurelian, GARBUZ, Olga, TSAPKOV, Victor I.. Crystal structures of [N′-(2- oxidobenzylidene)-N-(prop-2-en-1-yl)- carbamohydrazonothioato(2-)](1,10- phenanthroline)copper and [N′-(2- oxidobenzylidene)-N-(prop-2-en-1-yl)- carbamohydrazonothioato(2-)](2,2′- bipyridine)copper hemihydrates. In: Journal of Structural Chemistry, 2022, nr. 6(63), pp. 905-913. ISSN 0022-4766. DOI: https://doi.org/10.1134/S0022476622060075 |
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Journal of Structural Chemistry | ||||||
Numărul 6(63) / 2022 / ISSN 0022-4766 | ||||||
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DOI:https://doi.org/10.1134/S0022476622060075 | ||||||
Pag. 905-913 | ||||||
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Rezumat | ||||||
The crystal structures and biological properties of [N′-(2-oxidobenzylidene)-N-(prop-2-en-1-yl)-carbamohydrazonothioato(2-)](1,10-phenanthroline)copper hemihydrate [Cu(1,10-Phen)(L)]·0.5H2O (I) and [N′-(2-oxidobenzylidene)-N-(prop-2-en-1-yl)-carbamohydrazonothioato(2-)](2,2′-bipyridine)copper hemihydrate [Cu(2,2′-BPy)(L)]·0.5H2O (II), where Н2L is 2-(2-hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide, are determined. The asymmetric unit of the unit cell in the crystal structures of I and II contains a copper complex with bidentate amine and a ligand coordinated by the azomethine nitrogen atom, the deprotonated phenolic oxygen atom, and the sulfur atom in the thiol form. The coordination polyhedron of the copper atom in compounds I and II is a distorted tetragonal pyramid. Obtained coordination compounds I and II exhibit antimicrobial and antifungal activities and have minimum inhibitory concentration and bactericidal concentration values in a range of 1.5-500 µg/mL. The study of the antioxidant activity shows that compounds I and II are less active than uncoordinated thiosemicarbazone H2L, but more active than trolox used in medical practice. |
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