In the multi-layered Upper Paleolithic site of Cosauti (the Republic of Moldova), which is unique in the richness and variety of finds, unmodified or slightly processed stones with use-wear traces were found, in addition to numerous flint implements. Among the various groups of tools were identified by applying the use-wear analysis: hammer stones, anvils, abrasives, palettes or pigment grinders, polishers, lower and upper grinding stones. These tools were used in various types of economic activities and served to process various materials: antler, bones, skins, ocher, flint, and other types of stone, as well as for crushing, kneading, and grinding plant materials. The obtained data points out the efficient and selective use of different stone raw materials to create the tools for various purposes.